Maternal separation and social isolation modulate the postnatal development of synaptic composition in the infralimbic cortex of Octodon degus

Neuroscience
W Ovtscharoff, K Braun

Abstract

We analysed the influence of preweaning periodic maternal separation followed by postweaning chronic social isolation on the development of synaptic composition in the infralimbic cortex of Octodon degus, a South American species formerly classified as a caviomorph rodent but now considered to belong to Lagomorpha (rabbits). Three groups of animals were analysed: (1) control pups which remained undisturbed with their families; (2) pups which were exposed to individual periodic maternal deprivation [postnatal day 1 (P1) until P21], followed by social isolation (P22 until P45); and (3) pups which were handled daily without being removed from the families (P1 until P21) and thereafter remained undisturbed with the family (P22 until P45). The mean synaptic density and mean projected height of synapses were quantified using the "dissector" method. In the deprived group, significantly higher (up to 137.8%) mean synaptic densities were found in layer II of the infralimbic cortex compared to normal control animals. In handled pups, asymmetric shaft synapses were significantly decreased (down to 54%) compared to the control group.These results indicate that early postnatal changes in the socio-emotional environment change the number of ...Continue Reading

References

Jul 1, 1979·Annals of the Academy of Medicine, Singapore·M Rutter
Apr 1, 1979·Laboratory Animals·T J Reynolds, J W Wright
Dec 1, 1992·Journal of Morphology·J W Wright, M D Kern
Jun 8, 1991·The Journal of Comparative Neurology·K M HurleyC B Saper
Nov 22, 1991·The Journal of Comparative Neurology·R P Vertes
Dec 1, 1987·Brain Research Bulletin·R R Terreberry, E J Neafsey
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J P BourgeoisP Rakic
Jul 1, 1988·Journal of Microscopy·H J Gundersen
Sep 1, 1987·Journal of Microscopy·H J Gundersen, E B Jensen
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·W T GreenoughC Gorman
Sep 1, 1966·The Journal of Comparative Neurology·M C DiamondE L Bennett
Feb 1, 1973·Journal of Comparative and Physiological Psychology·A GlobusM C Diamond
Feb 20, 1995·The Journal of Comparative Neurology·F CondéF Crépel
Nov 1, 1994·Developmental Psychobiology·G SpanglerC Ackermann
Jun 1, 1996·Behavioural Brain Research·M R Rosenzweig, E L Bennett
Mar 1, 1996·Harvard Review of Psychiatry·J Kagan, M Zentner
Feb 5, 1998·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·S Braun, H Scheich
Jan 27, 1999·Developmental Psychobiology·V H Denenberg
Nov 5, 1999·Physiology & Behavior·C Michel, M Cabanac
Feb 1, 2000·Trends in Neurosciences·I SegalD D Murphy
Apr 14, 2000·Behavioural Brain Research·P M Wall, C Messier

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Citations

Dec 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Gerd PoeggelKatharina Braun
Aug 2, 2014·Behavioural Brain Research·Dayalan SampathT R Laxmi
Apr 24, 2012·Neuroscience Research·Gianluca SerafiniPaolo Girardi
Apr 26, 2011·Journal of Chemical Neuroanatomy·Yogesh Dwivedi
Feb 15, 2011·Hormones and Behavior·Megan Hastings HagenauerTheresa M Lee
Jun 16, 2007·Epilepsia·Cesare T Lombroso
Apr 16, 2013·The European Journal of Neuroscience·Agnieszka ChocykKrzysztof Wędzony
Jun 21, 2012·Developmental Psychobiology·Nim Tottenham
Jul 19, 2012·The European Journal of Neuroscience·Daniel L HummerTheresa M Lee
Jul 31, 2004·Brain Research. Developmental Brain Research·Russell D RomeoBruce S McEwen
Sep 16, 2014·The European Journal of Neuroscience·Syutaro ToyaNoriyuki Koibuchi
Jun 5, 2015·Frontiers in Molecular Neuroscience·Yusuke Takatsuru, Noriyuki Koibuchi
Feb 24, 2015·The Journal of Physiological Sciences : JPS·Yusuke TakatsuruNoriyuki Koibuchi
Sep 7, 2016·Behavioural Brain Research·Benjamin C NephewJean A King
Jul 31, 2016·Experimental Physiology·Nikita N BurkeTuan Trang
Feb 15, 2018·Frontiers in Cellular Neuroscience·Dávid CsabaiBoldizsár Czéh
Nov 23, 2017·The Journal of Physiological Sciences : JPS·Michifumi KokuboYusuke Takatsuru
Apr 13, 2007·Language, Speech, and Hearing Services in Schools·Ineke WayConnie Black-Pond
May 5, 2017·Frontiers in Cellular Neuroscience·Miranda van BodegomMarloes J A G Henckens
Aug 19, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Daniel L HummerTheresa M Lee

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