Maternal serum activin A and the prediction of intrauterine growth restriction

The Australian & New Zealand Journal of Obstetrics & Gynaecology
Andrea Barkehall-ThomasEuan M Wallace

Abstract

Differentiating between the small healthy fetus and the high risk growth restricted fetus remains a significant obstetric challenge. It has been previously shown that maternal activin A levels are increased in association with fetal growth restriction. To evaluate maternal serum activin A as a marker of fetal growth restriction. Prospective cohort study of 62 women referred for fetal assessment because of a clinical suspicion of a small for gestation fetus. Maternal serum levels of activin A were measured with an ELISA. Activin A levels, expressed as median (95% CI) MoMs, were similar in the women with a normal-sized fetus and in those with a healthy small for gestational age fetus, 1.14 (95% CI 1.0-1.5) and 1.31 (95% CI 0.8-2.1), respectively (P = 0.97). Compared to the women with a normal-sized fetus or a healthy small fetus, activin A levels were significantly elevated in the women who had an intrauterine fetal growth restriction fetus 2.37 (95% CI 1.6-3.7; P = 0.01 compared to normal and P = 0.04 compared to healthy small). These data confirm that circulating activin A is increased in association with fetal growth restriction. However, a single blood sample for activin A will not efficiently discern between healthy and comp...Continue Reading

References

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Citations

Jul 31, 2009·Journal of Perinatology : Official Journal of the California Perinatal Association·R HodgesE M Wallace
Mar 7, 2009·Prenatal Diagnosis·Laura L Jelliffe-PawlowskiRobert J Currier
Feb 20, 2009·Prenatal Diagnosis·Winnie W I PangRossa W K Chiu
Jun 1, 2011·Australian Dental Journal·J G Lee, L J Brearley Messer
Apr 28, 2006·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Stephen Tong

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