PMID: 6158991Oct 1, 1980Paper

Maternal serum alpha-fetoprotein and birth weight

British Journal of Obstetrics and Gynaecology
N WaldA C Turnbull

Abstract

Maternal serum alpha-fetoprotein (AFP) levels between 16 and 18 weeks of pregnancy were studied in relation to birth weight among 4198 singleton pregnancies resulting in a liveborn or stillborn infant without a neural tube defect. The highest mean birth weight (3365 g) was found among infants born to women with AFP values in the range 0.50 to 0.74 times the normal median for the relevant week of gestation. As the AFP decreased from this level to less than 0.25 times the median, the birth weight decreased by 193 g and the proportion of infants weighing 2500 g or less increased from 4 per cent to 11 per cent. As the AFP level increased from 0.50 to 0.74 times the median to 3.0 times the median or greater, the birth weight decreased by 371 g and the proportion of infants weighing 2500 g or less increased from 4 to 22 per cent. The negative association was the more important of the two since the magnitude was greater and it affected 92 per cent of pregnancies. The positive association among women with low ARP levels was substantially reduced when the analysis was restricted to women who had spontaneous labours. It seems that this minor positive association arises mainly because women in whom gestation is over-estimated tend to have...Continue Reading

References

Aug 6, 1977·Lancet·N WaldA C Turnbull
Mar 25, 1978·Lancet·J N MacriM A Cagan
Feb 24, 1979·Lancet·A S Pacsa, B Pejtsik
Oct 15, 1979·American Journal of Obstetrics and Gynecology·M J BennettN J Wald
Feb 2, 1980·Lancet·N J Wald, H S Cuckle

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Citations

Jun 1, 2002·Obstetrics and Gynecology·Ahmet A BaschatJane A Evans
Aug 27, 1983·British Medical Journal·M P Moore, C W Redman
May 1, 1982·British Journal of Obstetrics and Gynaecology·D J BrockA J Keay
Nov 1, 1985·The Australian & New Zealand Journal of Obstetrics & Gynaecology·M LeggeD R Aickin
Mar 1, 1982·British Journal of Obstetrics and Gynaecology·N J WaldA C Turnbull
May 4, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Eita Goto
May 16, 2003·Prenatal Diagnosis·T HuangN J Wald
Mar 1, 1996·British Journal of Obstetrics and Gynaecology·S HeinonenS Saarikoski
Jun 1, 1986·British Journal of Obstetrics and Gynaecology·J E HaddowG E Palomaki
Jan 1, 1986·British Journal of Obstetrics and Gynaecology·T ChardA M Nysenbaum
Jan 1, 1988·British Journal of Obstetrics and Gynaecology·D J Brock, L Barron
Aug 1, 1984·British Journal of Obstetrics and Gynaecology·L J Sant-CassiaA J Tyack
Aug 1, 1983·British Journal of Obstetrics and Gynaecology·S G ThomsenV Schiølier
Mar 1, 1981·British Journal of Obstetrics and Gynaecology·G M StirratH S Cuckle

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