PMID: 69879Aug 6, 1977Paper

Maternal serum-alpha-fetoprotein and low birth-weight

Lancet
N WaldA C Turnbull

Abstract

High maternal serum-alpha-fetoprotein (A.F.P.) concentrations in the first half of pregnancy were associated with prematurity and high perinatal mortality. 94 singleton pregnancies without neural-tube defects but with A.F.P. levels equal to or greater than three times the normal median resulted in the birth of infants weighing, on average, 357 g less than controls (P less than 0-001). The mean head circumference of the infants was also smaller than that of the controls. The 1 stillbirth and 3 neonatal deaths yielded a mortality-rate more than three and a half times that for singleton births without neural-tube defects at the same hospital in the years 1974-76. The results suggest that some pregnant women who will deliver low-birth-weight infants at high risk of perinatal death may be identified by means of serum-A.F.P. measurement early in pregnancy.

Citations

Mar 1, 1983·Indian Journal of Pediatrics·A GuptaP S Menon
Feb 24, 1979·Lancet·A S Pacsa, B Pejtsik
May 1, 1978·British Journal of Obstetrics and Gynaecology·M J BennettA C Turnbull
Aug 1, 1978·British Journal of Obstetrics and Gynaecology·N J Wald, H Cuckle
Jul 1, 1978·British Journal of Obstetrics and Gynaecology·Z KeilaniT Chard
Dec 1, 1978·British Journal of Obstetrics and Gynaecology·S K KhooE V Mackay
Feb 1, 1979·British Journal of Obstetrics and Gynaecology·N J WaldC J Evans
Sep 1, 1979·British Journal of Obstetrics and Gynaecology·D J BrockJ B Scrimgeour
May 1, 1990·British Journal of Obstetrics and Gynaecology·A AristidouK Nicolaides
Aug 5, 1998·American Journal of Reproductive Immunology : AJRI·R F FraserP Coney
Sep 20, 1980·British Medical Journal·R HarrisP Donnai
Oct 29, 1983·British Medical Journal·B N WaltersM de Swiet
Jan 1, 1984·Journal of Perinatal Medicine·C M BucklandA G Campbell
Jan 1, 1986·British Journal of Obstetrics and Gynaecology·T ChardA M Nysenbaum
Nov 1, 1986·British Journal of Obstetrics and Gynaecology·E M Walker, N B Patel
Jan 1, 1988·British Journal of Obstetrics and Gynaecology·D J Brock, L Barron
May 1, 1982·British Journal of Obstetrics and Gynaecology·D J BrockA J Keay
Aug 1, 1980·British Journal of Obstetrics and Gynaecology·P J ToplisJ Dewhurst
Oct 1, 1980·British Journal of Obstetrics and Gynaecology·N J WaldA C Turnbull
Oct 1, 1982·British Journal of Obstetrics and Gynaecology·A GhoshM A Ferguson-Smith
Aug 25, 2001·Paediatric and Perinatal Epidemiology·C HolzmanUNKNOWN Prematurity Study Group
May 4, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Eita Goto
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Mar 16, 2007·Fetal Diagnosis and Therapy·Jose L BarthaPeter W Soothill
Dec 1, 1980·British Journal of Obstetrics and Gynaecology·M L Smith

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