Maternal serum androgens in human pregnancy: early increases within the cycle of conception

Human Reproduction
V D CastracaneB L Lasley

Abstract

Previous studies have demonstrated elevations in testosterone and androstenedione initiated within the cycle of conception in pregnant non-human primates, and minimal data in the human support the same picture. In the present study we have investigated a group of patients scheduled for artificial insemination with regular menstrual cycles. For this study all patients provided blood samples at 5 days after the luteinizing hormone (LH) surges and daily through the luteal phase and into early pregnancy (n = 12). Patients who did not become pregnant served as normal controls (n = 9). We have measured 17-hydroxyprogesterone (17-OHP) as a marker of luteal activity not obscured by progesterone within the cycle of conception and testosterone and androstenedione as the major androgens. There were no significant changes in testosterone and androstenedione in the non-pregnant controls, but both testosterone and androstenedione were significantly elevated in the pregnant luteal phase, with the first increases occurring at 15 and 14 days respectively after the LH surge. Three of 12 pregnant patients did not demonstrate a dramatic increase in either testosterone or androstenedione and when examined more carefully a corresponding lack of incr...Continue Reading

Citations

Feb 13, 2001·The Journal of Steroid Biochemistry and Molecular Biology·L P LovelyB A Lessey
Aug 14, 1998·Environmental Health Perspectives·B L Lasley, J W Overstreet
Mar 20, 2014·Human Reproduction Update·Sofia MakievaJane E Norman
Aug 1, 2015·Molecular Reproduction and Development·Jingjie XuHaibin Kuang
Apr 12, 2005·Fertility and Sterility·Pete N LohstrohBill L Lasley
Feb 13, 2015·PloS One·Ellane R CleysGerrit J Bouma
Sep 10, 2004·American Journal of Primatology·Alyssa M PufferKimberly J Patera
Aug 21, 2014·Endocrine Reviews·Birgit Gellersen, Jan J Brosens

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