Maternal serum Ca125 and Ca15-3 antigen levels in normal and pathological pregnancy

Fetal Diagnosis and Therapy
G G BonJ M van Vugt

Abstract

To evaluate the value of maternal serum CA125 and CA15-3 concentrations for discriminating pathological from normal pregnancies. Serum samples from 120 women, in whom pregnancy outcome was pathological, i.e. spontaneous abortion, fetal death, intrauterine growth retardation, chromosomal and structural abnormalities, and (pre)eclampsia, were assessed for CA125 and CA15-3 and compared with levels found in 350 women with a normal pregnancy outcome matched for age and duration of pregnancy. Maternal CA125 serum values were significantly higher in the first and the third trimester of pregnancy (median 23.0 and 21.0 U/ml; p < 0.00001 and p < 0.001, respectively), compared to those in the second trimester (median 14.0 U/ml), but not significantly different from those obtained in pathological pregnancies. Maternal serum CA15-3 values were significantly higher during the third trimester (median 26.0 U/ml) compared to the first and second trimester of pregnancy (median 14.0 and 15.0 U/ml; p < 0.0001); CA15-3 serum levels in normal and pathological pregnancies showed no significant difference. Maternal serum levels of CA125 are higher during the first and third trimester of pregnancy. CA15-3 maternal serum levels are higher during the thi...Continue Reading

Citations

Nov 4, 2010·Archives of Gynecology and Obstetrics·Mustafa OzatLeyla Mollamahmutoglu
Jul 28, 2011·Archives of Gynecology and Obstetrics·Şerif ErcanAsuman Orçun
Aug 23, 2011·Archives of Gynecology and Obstetrics·Friederike HoellenMichael K Bohlmann
Dec 31, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Zhihui HeWenrui Jin
May 27, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Simone P PinheiroDaniel W Cramer
Aug 28, 2009·Gynécologie, obstétrique & fertilité·H MarretUNKNOWN CNGOF
Apr 9, 2010·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·M A OsmanağaoğluH Bozkaya
Nov 3, 2005·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·S A El-ShawarbyM A Mossa
Aug 30, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ming ShiFanggui Ye
Apr 10, 2012·Taiwanese Journal of Obstetrics & Gynecology·Fu-Nan ChoKen-Jen Yu
Mar 3, 2012·American Journal of Reproductive Immunology : AJRI·Chanel TylerManish S Patankar
Sep 2, 2014·Acta Obstetricia Et Gynecologica Scandinavica·Pal B SzecsiSteen Stender
Sep 10, 2003·Emergency Medicine Clinics of North America·Paolo T Coppola, Marco Coppola
Jan 1, 2011·Cancers·Silvia Von Mensdorff-PouillyRené H M Verheijen
May 3, 2018·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Gbemisola E OsanyinAyodeji Ayotunde Oluwole
Oct 19, 2004·Acta Obstetricia Et Gynecologica Scandinavica·Ulla Breth KnudsenOle Mogensen
Mar 12, 2019·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Inanc KarakoyunBanu Isbilen Basok
Mar 17, 2007·Critical Reviews in Clinical Laboratory Sciences·Angeliki SarandakouDemetrios Rizos
May 14, 2009·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Fatma Bahar CebesoyYelda Ibar
Dec 13, 2019·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Hakan ErenelPelin Ocal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Acta Obstetricia Et Gynecologica Scandinavica
C BaykalI Dölen
European Journal of Obstetrics, Gynecology, and Reproductive Biology
M MikamiC Tei
© 2021 Meta ULC. All rights reserved