Maternal serum concentration of soluble fms-like tyrosine kinase 1 and vascular endothelial growth factor in women with abnormal uterine artery Doppler and in those with fetal growth restriction

American Journal of Obstetrics and Gynecology
M SavvidouKypros H Nicolaides

Abstract

This study was undertaken to determine whether maternal serum concentration of the angiogenic factor vascular endothelial growth factor (VEGF) and its circulating antagonist, soluble fms-like tyrosine kinase 1 (sFlt-1), which have been implicated in the pathogenesis of preeclampsia (PE), are altered in pregnancies that subsequently develop PE and in those with established fetal growth restriction (FGR). Three groups of healthy pregnant women at 23 to 25 weeks of gestation were examined: group A (n = 42) with normal uterine artery Doppler waveforms, group B (n = 49) with abnormal uterine artery Doppler waveforms, and group C (n = 15) with abnormal Doppler results and established FGR. Comparisons between multiple groups were performed by using 1-way analysis of variance or Kruskal-Wallis test. In group C, compared with group A, the median sFlt-1 was significantly higher (P < .0001) and VEGF was lower (P < .001). Group C included 3 women who had PE develop. In group B, 19 women had a normal outcome, 13 had PE develop, and 17 had FGR develop. There were no significant differences in sFlt-1 levels between any of the subgroups of group B and group A. Maternal serum concentration of sFlt-1 in pregnancies with FGR is increased but this...Continue Reading

References

Apr 1, 1988·American Journal of Obstetrics and Gynecology·D A Davey, I MacGillivray
Feb 13, 1999·American Journal of Obstetrics and Gynecology·C W RedmanI L Sargent
Aug 17, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B MeisterR Möhle
Feb 8, 2000·Biological Chemistry·P ScheideggerR Jaussi
Apr 5, 2001·Placenta·J M SikkemaE E van Faassen
Oct 4, 2002·Placenta·F Lyall
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·Ravi ThadhaniS Ananth Karumanchi
Feb 7, 2004·The New England Journal of Medicine·Richard J LevineS Ananth Karumanchi
Apr 5, 2005·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Tinnakorn ChaiworapongsaMoshe Mazor
Aug 16, 2005·American Journal of Obstetrics and Gynecology·Christina K H YuUNKNOWN Fetal Medicine Foundation Second Trimester Screening Group

❮ Previous
Next ❯

Citations

Mar 13, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Asmita V KulkarniSadhana R Joshi
Apr 13, 2012·Human Reproduction Update·P H AndraweeraC T Roberts
Mar 14, 2007·Current Opinion in Obstetrics & Gynecology·Aris T Papageorghiou, Karin Leslie
Apr 5, 2008·Current Opinion in Obstetrics & Gynecology·Wendy L Kinzler, Anthony M Vintzileos
Jun 27, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Colleen Glyde JulianLorna G Moore
Jun 9, 2011·Reproductive Biology and Endocrinology : RB&E·Marni JacobsAnthony W Ashton
Feb 15, 2011·American Journal of Epidemiology·Bjørn Olav ÅsvoldAnne Eskild
Jul 14, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Digna R Velez EdwardsScott M Williams
Feb 4, 2014·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·D BorrasA Perales
Jan 5, 2008·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Tinnakorn ChaiworapongsaRoberto Romero
Aug 26, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Tinnakorn ChaiworapongsaSonia S Hassan
May 13, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Roberto RomeroSonia S Hassan
Nov 11, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Juan Pedro KusanovicSonia S Hassan
Jan 9, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Thushari I AlahakoonVincent W Lee
May 1, 2008·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Offer ErezSonia S Hassan
May 20, 2008·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Haim A AbenhaimRobert A Kinch
Apr 1, 2015·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S BakalisK H Nicolaides
Sep 21, 2007·Kidney International·Y TaoC L Edelstein
Sep 25, 2008·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M D SavvidouK H Nicolaides
Jul 2, 2010·The Journal of Pathology·Joanna L JamesJudith E Cartwright
Jan 27, 2010·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·T ChaiworapongsaY Sorokin
May 15, 2015·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·C LesmesK H Nicolaides
Apr 1, 2015·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S BakalisK H Nicolaides
Apr 1, 2015·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·C FadigasK H Nicolaides
Dec 21, 2013·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Jordan Y Z LiJonathan M Gleadle
Jan 1, 2011·Pregnancy Hypertension·Berthold Huppertz
Nov 15, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Emre ZaferHasan Yuksel
May 5, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Kelly YamasatoGillian D Bryant-Greenwood
Jun 26, 2012·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Andrea LouiPetra Koehne
Sep 5, 2018·The Journal of Clinical Investigation·Jacqueline G ParchemRaghu Kalluri
Dec 7, 2007·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·F CrispiE Gratacós

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Related Papers

The New England Journal of Medicine
Vassilis TsatsarisJean Michel Foidart
The Journal of Clinical Endocrinology and Metabolism
Ravi ThadhaniS Ananth Karumanchi
Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
Kevin SpencerHamutal Meiri
Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
Kypros H NicolaidesH S Cuckle
© 2022 Meta ULC. All rights reserved