Maternal serum hCG and fetal nuchal translucency thickness for the prediction of fetal trisomies in the first trimester of pregnancy

British Journal of Obstetrics and Gynaecology
M L BrizotK H Nicolaides

Abstract

To compare the potential value of maternal serum total hCG and free beta-hCG in predicting the risk for fetal trisomies during the first trimester of pregnancy and to examine whether data on maternal hCG and fetal nuchal translucency thickness can be combined to derive risks. Maternal serum total hCG and free beta-hCG were measured in samples from 83 singleton pregnancies with fetal chromosomal abnormalities (trisomy 21 (n = 41), trisomy 18 (n = 19), trisomy 13 (n = 8) sex chromosome aneuploidies (n = 11), triploidy (n = 4) and 394 chromosomally normal controls at 10 to 13 weeks gestation. In all cases, the fetal nuchal translucency thickness was measured at the time of fetal karyotyping. In the 249 chromosomally normal controls with fetal nuchal translucency less than 3 mm, total hCG and free beta-hCG decreased significantly with increased fetal crown-rump length. In 145 chromosomally normal fetuses with nuchal translucency 3 to 9 mm total hCG and free beta-hCG were not significantly different from the 249 with nuchal translucency less than 3 mm. In fetuses with trisomy 21, total hCG and free beta-hCG were significantly higher, whereas in trisomies 18 and 13 levels were lower than in chromosomally normal controls. When the cut...Continue Reading

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Citations

May 1, 2002·Prenatal Diagnosis·Kypros H NicolaidesSimona Cicero
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