Maternal serum inhibin-A in pregnancies with insulin-dependent diabetes mellitus: implications for screening for Down's syndrome

Prenatal Diagnosis
N J WaldL George

Abstract

A nested case-control study using stored serum samples collected as part of a prospective study of the outcome of pregnancy was performed to investigate concentrations of (dimeric) inhibin-A in maternal serum between 15 and 22 weeks of pregnancy in 126 pregnancies among 92 women with insulin-dependent diabetes mellitus (IDDM). Each IDDM pregnancy was matched with two control singleton pregnancies for gestational age (same completed week) and duration of sample storage (same calendar quarter). The median inhibin-A level in the IDDM pregnancies was 0.88 multiples of the median (MOM) for pregnancies without IDDM at the same gestational age (P = 0.05) (95 per cent confidence interval 0.78-1.00) or 0.91 MOM after adjustment for maternal weight. These results enable inhibin-A values to be adjusted so that prenatal screening for Down's syndrome can be performed using this marker in IDDM pregnancies as well as in non-diabetic pregnancies.

References

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Citations

Jun 15, 2012·The Cochrane Database of Systematic Reviews·S Kate AlldredZarko Alfirevic
Mar 16, 2017·The Cochrane Database of Systematic Reviews·S Kate AlldredZarko Alfirevic
Dec 15, 2015·The Cochrane Database of Systematic Reviews·S Kate AlldredZarko Alfirevic
Dec 1, 2015·The Cochrane Database of Systematic Reviews·S Kate AlldredZarko Alfirevic
Apr 28, 2018·Archives of Gynecology and Obstetrics·Tracy M TomlinsonGil Gross
May 16, 2003·Prenatal Diagnosis·T HuangN J Wald
Dec 8, 2011·Journal of Korean Medical Science·Ji Young KwonJong Chul Shin
May 6, 2010·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·G R Devore
Apr 29, 1998·Current Opinion in Obstetrics & Gynecology·L S Chitty
Jan 1, 1997·Journal of Medical Screening·N J WaldA McGuire
Mar 16, 2017·The Cochrane Database of Systematic Reviews·S Kate AlldredZarko Alfirevic
Jul 21, 2000·Annals of Clinical Biochemistry·N P Groome, L W Evans
Jul 28, 2021·Journal of Perinatal Medicine·Meryl M SperlingKelly Yamasato

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