PMID: 11920898Mar 29, 2002Paper

Maternal serum leptin concentration during the second trimester of pregnancy: association with fetal chromosomal abnormalities

Prenatal Diagnosis
Demetrios RizosEmmanuel Salamalekis

Abstract

Recent studies suggest that leptin, the product of the obese gene, is produced by the placenta during pregnancy. The present study addressed the question whether second trimester maternal serum leptin could be altered by fetal Down syndrome or Edwards syndrome. Maternal serum leptin concentrations were measured in 18 pregnancies complicated with Down syndrome, six pregnancies complicated with Edwards syndrome and 183 uncomplicated pregnancies during the second trimester of pregnancy. The present results demonstrate that leptin concentrations in uncomplicated pregnancies slightly decrease from the 16th week of pregnancy, reaching a minimum of 18.8 ng/ml around the 20th week, and then rapidly increase to 28.2 ng/ml by the 24th week. Leptin correlation with maternal body weight decreases from r=0.695 at 16-17 week of gestation to r=0.544 at >22 weeks of gestation. There was no significant difference between the mean MoMs of Down syndrome- (0.926) or Edwards syndrome- (0.960) affected pregnancies and normal pregnancies (1.002). A weak correlation (r=0.18, p<0.02) was observed between corrected leptin MoMs and human chorionic gonadotrophin (hCG) MoMs in normal pregnancies. It is assumed that around the 20th week of pregnancy placent...Continue Reading

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Citations

Jul 13, 2002·Prenatal Diagnosis
Jul 12, 2012·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·A DemirS Guclu
Dec 1, 2015·Reproductive Biomedicine Online·Mariana A Costa
Jun 6, 2009·Reproductive Biomedicine Online·Paula HedleyMichael Christiansen
Apr 26, 2008·Prenatal Diagnosis·Paula Hedley, Michael Christiansen

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