Maternal smoking during pregnancy and long-term neurological morbidity of the offspring

Addictive Behaviors
Gil GutvirtzEyal Sheiner

Abstract

To evaluate the long-term pediatric neurological morbidity of children born to mothers who reported smoking during pregnancy as compared with children born to non-smoking mothers. A population-based cohort analysis was performed comparing all deliveries of mothers who reported smoking during pregnancy and non-smoking mothers between 1991 and 2014 at a single tertiary medical center. Hospitalizations of the offspring up to the age of 18 years involving neurological morbidities were evaluated according to a predefined set of ICD-9 codes, including autism, development and movement disorders, cerebral palsy and more. A Kaplan-Meier survival curve was used to compare cumulative hospitalization rate in exposed and unexposed offspring and a Cox proportional hazards model was used to control for confounders. During the study period, 242,342 deliveries met the inclusion criteria. Of them, 2861 (1.2%) were children of smoking mothers. Neurological-related hospitalizations were significantly higher in children born to smoking mothers, as compared with the non-smoking group (5.3% vs. 3.1%, p < 0.01). Specifically, these children had higher rates of movement, eating and developmental disorders as well as attention deficit hyperactive disord...Continue Reading

Citations

May 13, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Derya Adibelli, Nurcan Kirca
Sep 24, 2020·Journal of Clinical Medicine·Sharon DavideskoGali Pariente
Jun 8, 2021·Health Psychology Review·Lauren RockliffeDebbie M Smith
Aug 7, 2021·Brain Research Bulletin·Kartheek GaviniKodeeswaran Parameshwaran
Dec 22, 2021·Pediatric Pulmonology·Galia PelesEyal Sheiner

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