Maternal Smoking During Pregnancy and Timing of Puberty in Sons and Daughters: A Population-Based Cohort Study

American Journal of Epidemiology
N BrixCecilia H Ramlau-Hansen

Abstract

Because early puberty has been linked to diseases later in life, identification of modifiable causes of early puberty is of interest. We explored the possible associations between maternal smoking during pregnancy and pubertal development in sons and daughters. Between 2012 and 2017, 15,819 children from the Danish National Birth Cohort, born during 2000-2003, provided half-yearly information on puberty from the age of 11 years. We estimated adjusted age differences (in months) at attaining various pubertal milestones, including Tanner stages, per 10 daily cigarettes smoked in the first trimester of gestation. In sons, exposure to smoking in utero was associated with earlier genital development (Tanner 2, -1.3 months, 95% confidence interval (CI): -2.5, 0.0; Tanner 5, -3.7 months, 95% CI: -5.3, -2.0), pubic hair development (Tanner 2, -1.8 months, 95% CI: -2.9, -0.6; Tanner 5, -2.9 months, 95% CI: -4.2, -1.7), and voice break (-2.4 months, 95% CI: -3.6, -1.3). In daughters, maternal smoking was associated with earlier breast development (Tanner 2, -3.4 months, 95% CI: -5.3, -1.5; Tanner 5, -4.7 months, 95% CI: -6.5, -2.9), pubic hair development stages 3-5 (Tanner 5, -2.5 months, 95% CI: -4.1, -1.0), and menarche (-3.1 months, ...Continue Reading

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Citations

Nov 8, 2019·International Journal of Epidemiology·Andreas ErnstCecilia H Ramlau-Hansen
Jun 27, 2019·International Journal of Epidemiology·Nis BrixCecilia Høst Ramlau-Hansen
Jan 1, 2020·Scientific Reports·Sofie Aagaard SandCecilia Høst Ramlau-Hansen
Aug 9, 2020·Human Reproduction·Lea Lykke Harrits LunddorfCecilia H Ramlau-Hansen
May 7, 2020·International Journal of Epidemiology·Nis BrixCecilia Høst Ramlau-Hansena
Apr 23, 2020·Paediatric and Perinatal Epidemiology·Nis BrixCecilia Høst Ramlau-Hansen
Oct 6, 2020·Paediatric and Perinatal Epidemiology·Andreas ErnstCecilia Høst Ramlau-Hansen
Dec 24, 2020·Biology of Reproduction·Sijia YaoAmanda N Sferruzzi-Perri
Jun 2, 2021·Scandinavian Journal of Public Health·Anne Marie Ladehoff ThomsenAndreas Ernst
Jun 4, 2021·Paediatric and Perinatal Epidemiology·Julie J HvidtCecilia H Ramlau-Hansen
Nov 26, 2021·Australian and New Zealand Journal of Public Health·Angela RatschKathryn Steadman
Nov 27, 2021·Paediatric and Perinatal Epidemiology·Kun HuangCecilia Høst Ramlau-Hansen

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