Maternal smoking during pregnancy induces airway remodelling in mice offspring

The European Respiratory Journal
M J BlacquièreMachteld N Hylkema

Abstract

Children from smoking mothers have an increased risk of developing asthma for reasons largely unknown. The effects of maternal smoking during pregnancy on remodelling, allergic airway inflammation and hyperresponsiveness in offspring were investigated in an experimental asthma model. Mice were exposed to fresh air or cigarette smoke from 3 weeks prior to conception until birth. Offspring were exposed to house dust mite (HDM) or PBS intranasally four times per week from week 5 to week 10 after birth onwards. Maternal smoking increased airway smooth muscle layer, collagen III deposition and HDM-induced goblet cell numbers in offspring. It additionally increased methacholine responsiveness, which correlated significantly with increased airway smooth muscle layer and collagen deposition. Maternal smoking increased HDM-induced numbers of neutrophils and mast cells in lung tissue. No further effects were observed. Smoking during pregnancy induces airway remodelling in mice offspring, which may contribute to increased methacholine responsiveness. This takes place irrespective of allergen exposure but may worsen the outcome of the allergic stimulus, resulting in higher methacholine responsiveness in house dust mite-exposed offspring fr...Continue Reading

Citations

Mar 1, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jie LiuVirender K Rehan
Mar 26, 2010·American Journal of Respiratory and Critical Care Medicine·Dick Tibboel, Alan H Jobe
Sep 7, 2012·American Journal of Respiratory and Critical Care Medicine·Åsa NeumanUNKNOWN ENRIECO Consortium
Sep 25, 2012·American Journal of Respiratory Cell and Molecular Biology·Jie LiuVirender K Rehan
May 13, 2010·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Lin CorsonRachel L Miller
Mar 25, 2011·Journal of Toxicology and Environmental Health. Part a·Sung Gu HanDeepak K Bhalla
Jul 16, 2015·Expert Review of Respiratory Medicine·Valentina Fainardi, Sejal Saglani
Feb 11, 2014·Clinics in Chest Medicine·Dirkje S PostmaMaarten van den Berge
Jan 26, 2013·Paediatric Respiratory Reviews·Gert S Maritz
Jan 27, 2012·Seminars in Fetal & Neonatal Medicine·Richard Harding, Gert Maritz
Jan 5, 2011·Respiratory Physiology & Neurobiology·Kenneth L SandbergHåkan W Sundell
Oct 21, 2015·Paediatric Respiratory Reviews·Mary-Ann WagijoJasper V Been
Jun 1, 2013·Birth Defects Research. Part C, Embryo Today : Reviews·MaryJane K SelgradeMichelle A Cawley
Mar 28, 2013·Mediators of Inflammation·Christina DraijerBarbro N Melgert
Jul 10, 2014·Expert Opinion on Therapeutic Targets·Kuldeep KumawatReinoud Gosens
Jun 9, 2015·Clinical Epigenetics·Susanne Krauss-EtschmannMachteld N Hylkema
Nov 5, 2016·Environmental Health Perspectives·David DrummondChristophe Delacourt
Dec 7, 2018·The Journal of Pathology·Svenja LoeringPhilip M Hansbro
Dec 14, 2011·Nature Reviews. Immunology·Harald RenzMathias Hornef
Oct 5, 2013·Expert Review of Respiratory Medicine·Rodney D BrittY S Prakash
Aug 2, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kathleen J HaleyKelan Tantisira
Jan 29, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·K F MeyerM N Hylkema
Feb 11, 2020·Journal of Leukocyte Biology·Katie M LeboldMatthew G Drake
Feb 18, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Uchenna UnachukwuJeanine D'Armiento
Aug 12, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anouk OldenburgerMartina Schmidt
Jun 24, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Khosbayar LkhagvadorjMachteld N Hylkema
Oct 4, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Gerry T M WagenaarReinoud Gosens
Jun 15, 2016·Birth Defects Research. Part C, Embryo Today : Reviews·Bradley D Holbrook
Jan 1, 2011·Toxicological and Environmental Chemistry·Cynthia A Leifer, Rodney R Dietert
Oct 4, 2019·Birth Defects Research·Katherine M Kuniyoshi, Virender K Rehan
Sep 24, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Barbara HammerSusanne Krauss-Etschmann
Feb 21, 2019·Clinical Epigenetics·Razia ZakaryaBrian G Oliver
Aug 14, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Khosbayar LkhagvadorjMachteld N Hylkema
Mar 25, 2011·The Journal of Experimental Biology·Fatemeh TalaeiMartina Schmidt

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