Maternal stress and diet may influence affective behavior and stress-response in offspring via epigenetic regulation of central peptidergic function

Environmental Epigenetics
Annika Thorsell, Daniel Nätt

Abstract

It has been shown that maternal stress and malnutrition, or experience of other adverse events, during the perinatal period may alter susceptibility in the adult offspring in a time-of-exposure dependent manner. The mechanism underlying this may be epigenetic in nature. Here, we summarize some recent findings on the effects on gene-regulation following maternal malnutrition, focusing on epigenetic regulation of peptidergic activity. Numerous neuropeptides within the central nervous system are crucial components in regulation of homeostatic energy-balance, as well as affective health (i.e. health events related to affective disorders, psychiatric disorders also referred to as mood disorders). It is becoming evident that expression, and function, of these neuropeptides can be regulated via epigenetic mechanisms during fetal development, thereby contributing to the development of the adult phenotype and, possibly, modulating disease susceptibility. Here, we focus on two such neuropeptides, neuropeptide Y (NPY) and corticotropin-releasing hormone (CRH), both involved in regulation of endocrine function, energy homeostasis, as well as affective health. While a number of published studies indicate the involvement of epigenetic mechan...Continue Reading

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Citations

Mar 20, 2019·Current Nutrition Reports·Andrea Fuso, Marco Lucarelli
Jul 26, 2016·Environmental Epigenetics·Rodriguez-Martinez Heriberto
Apr 2, 2019·Frontiers in Nutrition·Veronica LazarMariana Carmen Chifiriuc
Nov 10, 2021·Translational Psychiatry·Emily DrzymallaAnke Hüls
Jul 13, 2020·Current Stem Cell Research & Therapy·Özlem Altundag, Betül Çelebi-Saltik

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Methods Mentioned

BETA
environmental stress
acetylation
histone acetylation
in vitro transcription

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