Abstract
The early-life environment critically influences neurodevelopment and later psychological health. To elucidate neural and environmental elements that shape emotional behavior, we developed a rat model of individual differences in temperament and environmental reactivity. We selectively bred rats for high versus low behavioral response to novelty and found that high-reactive (bred high-responder, bHR) rats displayed greater risk-taking, impulsivity and aggression relative to low-reactive (bred low-responder, bLR) rats, which showed high levels of anxiety/depression-like behavior and certain stress vulnerability. The bHR/bLR traits are heritable, but prior work revealed bHR/bLR maternal style differences, with bLR dams showing more maternal attention than bHRs. The present study implemented a cross-fostering paradigm to examine the contribution of maternal behavior to the brain development and emotional behavior of bLR offspring. bLR offspring were reared by biological bLR mothers or fostered to a bLR or bHR mother and then evaluated to determine the effects on the following: (1) developmental gene expression in the hippocampus and amygdala and (2) adult anxiety/depression-like behavior. Genome-wide expression profiling showed th...Continue Reading
Citations
Jun 15, 2017·The European Journal of Neuroscience·Joshua L CohenSarah M Clinton
Jun 28, 2018·Bioscience Reports·Chelsea R McCoySarah M Clinton
Dec 27, 2018·The European Journal of Neuroscience·Matthew E GloverSarah M Clinton
Apr 1, 2018·Genes, Brain, and Behavior·K Y Sarkisova, A V Gabova
Oct 17, 2015·Stress : the International Journal on the Biology of Stress·Samir RanaIlan A Kerman
Apr 18, 2019·Hippocampus·Allie J WidmanSarah M Clinton
Nov 30, 2020·The European Journal of Neuroscience·Elizabeth A ShupeSarah M Clinton
Jul 23, 2019·Progress in Neuro-psychopharmacology & Biological Psychiatry·Chelsea R McCoySarah M Clinton
Aug 9, 2020·Biological Psychiatry·Isabelle A BirtHuda Akil
Feb 12, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Sarah M ClintonMatthew E Glover
Feb 5, 2021·Neuroscience·M E GloverS M Clinton
May 31, 2021·Developmental Psychobiology·Elizabeth A Shupe, Sarah M Clinton
Jul 23, 2021·Neuroscience·Keaton A UnroeSarah M Clinton
Feb 26, 2021·The European Journal of Neuroscience·Sarah M ClintonIlan A Kerman