PMID: 8942837Dec 1, 1996Paper

Maternal theophylline administration and breathing movements in late-gestation human fetuses

Obstetrics and Gynecology
M IshikawaT Araki

Abstract

To investigate the relation between maternal administration of theophylline and breathing movements during late gestation in human fetuses. After a 1-hour control period, 17 women with normally grown fetuses at 33-38 weeks' gestation were given 400 mg of sustained-release theophylline orally. Maternal plasma theophylline and glucose concentrations were measured every hour, and the incidence of fetal breathing movements and breathing rates were measured continuously during the next 8 hours. Results were compared with those of a similar control group that did not receive theophylline. The maternal plasma theophylline concentration increased to detectable levels after 1 hour, reached therapeutic levels of 6.9 +/- 0.4 micrograms/mL (standard error of the mean) after 6 hours, and thereafter averaged 8.3 +/- 0.3 micrograms/mL, significantly higher than initial control values (P < .05). The mean glucose concentration was unchanged during the first 6 hours (79.2 +/- 1.1 mg/dL) and then decreased somewhat, averaging 75.8 +/- 1.1 mg/dL in the 7-8 hour period. The incidence of fetal breathing increased 26.4 +/- 1.9% after 5 hours and remained elevated during the next 3 hours at levels significantly higher than in the initial control perio...Continue Reading

References

May 1, 1991·Respiration Physiology·J M BissonnetteS J Knopp
Aug 1, 1990·Pediatric Research·J M BissonnetteN F Notoroberto
May 1, 1989·American Journal of Obstetrics and Gynecology·H S Salvador, B J Koos
Jan 1, 1984·American Journal of Perinatology·K P HoldenC M Peterson
Aug 1, 1983·Respiration Physiology·F L EldridgeJ P Kiley
Jan 1, 1984·Acta Obstetricia Et Gynecologica Scandinavica·M RonG Kidroni
May 1, 1981·Pediatric Research·I R Moss, E M Scarpelli
Apr 1, 1982·Early Human Development·J G NijhuisR S Bots
Sep 1, 1994·American Journal of Obstetrics and Gynecology·Y YoneyamaT Araki
Oct 15, 1993·Brain Research. Developmental Brain Research·J M Wilkinson, I Pollard

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Citations

Sep 25, 2004·Critical Care Clinics·Elizabeth S GuyNicola A Hanania
Aug 16, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·S M K BuckleyC Coutelle
Jun 16, 2001·Journal of Applied Physiology·K KobayashiJ J Greer

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