Maternal thrombophilias are associated with specific placental lesions

Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
Navneet Gogia, Geoffrey A Machin

Abstract

Maternal floor infarction (MFI), massive perivillous fibrin deposition (MPVFD), and fetal thrombotic vasculopathy (FTV) are specific placental lesions with associations to recurrent adverse fetal outcomes and with maternal thrombophilia. We studied the frequency of a range of acquired and genetic maternal thrombophilias in MFI (40 cases), MPVFD (87 cases), FTV (7 cases), and FTV+MPVFD (4 cases). Thrombophilias were identified in 16 (40%), 20 (23%), 5 (71%), and 2 (50%) of these lesions, respectively. Seventy-seven percent of the identified thrombophilias were genetic, and 23% were acquired. The most common genetic thrombophilia was protein S deficiency, which constituted 14 of the 36 genetic thrombophilias (39%). We advocate full maternal thrombophilia testing when the diagnosis of MFI, MPVFD, and FTV is made by placental pathology examination. Because of the possible contribution of paternal thrombophilic mutations to the fetal genotype, it would be desirable to test the whole family as well.

References

Jan 16, 1975·The New England Journal of Medicine·R D Rosenberg
May 5, 1994·Nature·P W Majerus
May 13, 1998·Archives of Disease in Childhood. Fetal and Neonatal Edition·O DebusU Nowak-Göttl
Jan 8, 1999·The New England Journal of Medicine·M J KupfermincJ B Lessing
Dec 22, 1999·Obstetrical & Gynecological Survey·C J Lockwood
Oct 6, 2000·The New England Journal of Medicine·I MartinelliP M Mannucci
Aug 3, 2001·American Journal of Obstetrics and Gynecology·T Y Khong, W M Hague
Jan 23, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Zarko AlfirevicVanessa Martlew
Mar 23, 2002·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Philip J Katzman, David R Genest
Jun 18, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·N J SebireL Regan
Sep 25, 2003·Human Pathology·Raymond W RedlineDinesh Shah
Jun 10, 2004·Human Pathology·Ilana ArielRaymond W Redline
Aug 5, 2004·Annals of Neurology·Otfried M DebusUlrike Nowak-Göttl
Nov 10, 2004·Current Opinion in Obstetrics & Gynecology·Lindsay RobertsonIan Greer
Nov 18, 2004·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Raymond W RedlineC Maureen Sander
Apr 4, 2006·American Journal of Obstetrics and Gynecology·Catherine S GibsonUNKNOWN South Australian Cerebral Palsy Research Group

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Citations

Nov 12, 2013·Journal de gynécologie, obstétrique et biologie de la reproduction·P Marcorelles
Feb 4, 2010·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Beverly Barton RogersRonald J Wapner
Jul 4, 2012·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Adrienne Carruth GriffinLinda M Ernst
Aug 1, 2013·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Rebecca L LinnLinda M Ernst
Dec 3, 2014·Seminars in Perinatology·Raymond W Redline
Aug 15, 2015·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Mana Taweevisit, Paul Scott Thorner
Mar 1, 2013·Surgical Pathology Clinics·Ona Marie Faye-Petersen, Linda M Ernst
Oct 10, 2013·The Journal of Obstetrics and Gynaecology Research·Nada Al-SahanAndrée Gruslin
Jan 17, 2014·The Journal of Obstetrics and Gynaecology Research·Bada JeongAhm Kim
Sep 10, 2011·American Journal of Obstetrics and Gynecology·Sharon M CooleyFionnuala M McAuliffe
Dec 19, 2009·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Mana Taweevisit, Paul Scott Thorner
Oct 27, 2017·Archives of Pathology & Laboratory Medicine·Amer Heider
Dec 23, 2017·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Athena Chen, Drucilla J Roberts
Oct 10, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Julien ChevreauJean Gondry
Jan 17, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Roberto OreficeJane E Dahlstrom
Jul 28, 2010·Clinical Obstetrics and Gynecology·Erika F Werner, Charles J Lockwood
May 14, 2020·Journal of Assisted Reproduction and Genetics·Jelena MilenkovicNovica Bojanic
Aug 26, 2020·The Journal of Obstetrics and Gynaecology Research·Esin KaymazKazım G Ozmen
Sep 22, 2020·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Mana TaweevisitPaul Scott Thorner
Oct 27, 2020·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Catherine K GestrichSanjita Ravishankar
Dec 3, 2020·Fetal and Pediatric Pathology·Sihem Darouich, Aida Masmoudi
Nov 7, 2020·American Journal of Reproductive Immunology : AJRI·Chloe A BradyIan P Crocker

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