Maternal-to-zygotic transition as a potential target for niclosamide during early embryogenesis

Toxicology and Applied Pharmacology
Sara M F VlietDavid C Volz

Abstract

Niclosamide is an antihelminthic drug used worldwide for the treatment of tapeworm infections. Recent drug repurposing screens have highlighted the broad bioactivity of niclosamide across diverse mechanisms of action. As a result, niclosamide is being evaluated for a range of alternative drug-repurposing applications, including the treatment of cancer, bacterial infections, and Zika virus. As new applications of niclosamide will require non-oral delivery routes that may lead to exposure in utero, it is important to understand the mechanism of niclosamide toxicity during early stages of embryonic development. Previously, we showed that niclosamide induces a concentration-dependent delay in epiboly progression in the absence of effects on oxidative phosphorylation - a well-established target for niclosamide. Therefore, the overall objective of this study was to further examine the mechanism of niclosamide-induced epiboly delay during zebrafish embryogenesis. Based on this study, we found that (1) niclosamide exposure during early zebrafish embryogenesis resulted in a decrease in yolk sac integrity with a concomitant decrease in the presence of yolk sac actin networks and increase in cell size; (2) within whole embryos, niclosamid...Continue Reading

References

Jan 1, 1982·Pharmacology & Therapeutics·P AndrewsD Lorke
Jul 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C B KimmelT F Schilling
Aug 31, 2000·Annual Review of Biochemistry·M Ibba, D Soll
Apr 16, 2003·Differentiation; Research in Biological Diversity·Ray KellerDavid R Shook
Aug 17, 2004·Trends in Cell Biology·Cynthia DeRenzo, Geraldine Seydoux
Sep 15, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jackie C ChengSarah E Webb
Mar 31, 2005·Current Biology : CB·Lilianna Solnica-Krezel
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Jul 18, 2009·Current Opinion in Genetics & Development·Elliott W Abrams, Mary C Mullins
Sep 24, 2009·Biochemistry·Minyong ChenWei Chen
Aug 17, 2010·The International Journal of Developmental Biology·Stephanie E Lepage, Ashley E E Bruce
Dec 21, 2012·Antimicrobial Agents and Chemotherapy·Francesco ImperiLivia Leoni
Jan 29, 2013·Molecular Aspects of Medicine·Lei LiJurrien Dean
Apr 17, 2013·Current Topics in Developmental Biology·Rachel Duffié, Déborah Bourc'his
Sep 1, 2007·Metabolomics : Official Journal of the Metabolomic Society·Lloyd W SumnerMark R Viant
Jan 31, 2014·Environmental Science & Technology·Emma L SchymanskiJuliane Hollender
Apr 16, 2014·Cancer Letters·Yonghe LiDonald J Buchsbaum
Dec 9, 2010·ACS Medicinal Chemistry Letters·Xiaomei RenKe Ding
Oct 9, 2014·Development·Alexander R LangleySteven A Harvey
Sep 12, 2015·Current Topics in Developmental Biology·Valeria Yartseva, Antonio J Giraldez
Apr 9, 2017·Cellular Signalling·Wei ChenJiangbo Wang
Jun 18, 2017·Toxicology and Applied Pharmacology·Sara M VlietDavid C Volz
Jul 7, 2017·Open Biology·Asmita Dutta, Deepak Kumar Sinha
Jan 7, 2018·International Journal of Biological Macromolecules·Vijayakumar RajendranTimir Tripathi
Mar 1, 2018·Scientific Reports·Nagendran TharmalingamEleftherios Mylonakis
Dec 16, 2018·Bioorganic & Medicinal Chemistry Letters·Robert A MookWei Chen
Mar 8, 2019·The Biochemical Journal·Phillip T Newton
Mar 17, 2019·Cells·Yajun LiuMin Li
Mar 29, 2019·Antimicrobial Agents and Chemotherapy·Ronald DomalaonFrank Schweizer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Related Papers

Toxicological Sciences : an Official Journal of the Society of Toxicology
Sara M F VlietDavid C Volz
Annals of Internal Medicine
R D Pearson, E L Hewlett
The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry
Beuy Joob, Viroj Wiwanitkit
© 2021 Meta ULC. All rights reserved