Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Claudia Fecher-TrostPetra Weissgerber

Abstract

Embryonic growth and bone development depend on placental Ca2+ transport across the feto-maternal barrier to supply minerals to the fetus. The individual factors and cellular mechanisms that regulate placental Ca2+ transfer, however, are only beginning to emerge. We find that the Ca2+ -selective transient receptor potential vanilloid 6 (TRPV6) channel is expressed in trophoblasts of the fetal labyrinth, in the yolk sac, and in the maternal part of the placenta. Lack of functional TRPV6 channels in the mother leads to a reduced Ca2+ content in both placenta and embryo. Ca2+ uptake in trophoblasts is impaired in the absence of Trpv6. Trpv6-deficient embryos are smaller, have a lower body weight, and shorter and less calcified femurs. The altered cortical bone microarchitecture persists in adulthood. We show that TRPV6's Ca2+ -conducting property causes this embryonic and bone phenotype. Our results show that TRPV6 is necessary for the Ca2+ uptake in trophoblasts and that TRPV6 deficiency in the placenta leads to reduced embryo growth, minor bone calcification, and impaired bone development. © 2019 American Society for Bone and Mineral Research.

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Citations

Feb 20, 2020·The Journal of Physiology·Maria V YelshanskayaAlexander I Sobolevsky
Aug 10, 2019·Cellular and Molecular Gastroenterology and Hepatology·Megan R BeggsR Todd Alexander
Jan 23, 2021·RSC Medicinal Chemistry·Micael Rodrigues CunhaJean-Louis Reymond
Feb 22, 2021·Biochimica Et Biophysica Acta. General Subjects·Verena NettUlrich Wissenbach
Sep 19, 2019·ACS Medicinal Chemistry Letters·Micael R CunhaJean-Louis Reymond

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