Maternal treatment with oleoyl-estrone induces resistance to lipid accrual in their descendants

Obesity
B García-PeláezX Remesar

Abstract

To determine whether treatment of rat dams with oleoyl-estrone (OE) has an effect on the offspring's long-term response to diet restriction during lactation. Control, OE-treated, and diet-restricted dams were treated up to day 15 of lactation. Changes in food intake and body weight were recorded for dams and their pups. After weaning, pups received a 4-week standard diet followed by a 4-week period of high-fat diet. Lipid, protein, and energy content of pups plus energy intake and efficiency. Serum metabolites (glucose, urea, and cholesterol) and serum hormones (adiponectin, leptin, insulin, and sexual hormones). Neither pups from dams in the OE-treated nor in the diet-restricted group showed significant changes in weight, though these two groups ingested 79% of food ingested by controls. At weaning, the pups from OE-treated rats were smaller than those of the control or diet-restricted groups. These pups maintained the differences in size and lipid content during the 4-week standard-diet period, whereas pups from diet-restricted dams showed a sharp decrease in their lipid content. During the 4 weeks of high-fat diet, the male offspring from OE-treated dams increased the difference in lipid content in relation to the pups from ...Continue Reading

References

Oct 1, 1982·The Journal of Nutrition·R CañasR L Baldwin
Aug 1, 1994·The British Journal of Nutrition·I RafecasM Alemany
Dec 1, 1995·Physiology & Behavior·M K McGuireK M Rasmussen
May 26, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C AdánM Alemany
Dec 22, 1999·The Proceedings of the Nutrition Society·S E Ozanne, C N Hales
Apr 27, 2001·Obesity Research·M del Mar GrasaM Alemany
Jan 30, 2002·The American Journal of Clinical Nutrition·Víctor M RodríguezAndreu Palou
Aug 8, 2002·The Journal of Nutritional Biochemistry·Ci;ntia TeixeiraEgberto Moura
Aug 22, 2002·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·C de Oliveira CravoC Ramos
Feb 14, 2004·Nutrition·Debora EstadellaClaudia M Oller Do Nascimento
Aug 7, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mina DesaiMichael G Ross
Aug 18, 2005·Experimental Physiology·Margaret J MorrisTimothy J Cole
Sep 15, 2005·American Journal of Obstetrics and Gynecology·Mina DesaiMichael G Ross
Sep 20, 2005·The Journal of Nutritional Biochemistry·Montserrat VadilloMayte Blay Olivé
Jun 20, 2006·The Journal of Nutritional Biochemistry·Egberto Gaspar de MouraMagna Cottini Fonseca Passos
Jul 4, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Barry E Levin
Dec 14, 2006·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·F P TosteM C F Passos
Apr 21, 2007·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·B García-PeláezX Remesar
Aug 23, 2007·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·B García-PeláezX Remesar

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Citations

Feb 3, 2011·Medicinal Research Reviews·Xavier RemesarMarià Alemany

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