Maternal undernutrition and the ovine acute phase response to vaccination

BMC Veterinary Research
P D EckersallStewart M Rhind

Abstract

The acute phase response is the immediate host response to infection, inflammation and trauma and can be monitored by measuring the acute phase proteins (APP) such as haptoglobin (Hp) or serum amyloid A (SAA). The plane of nutrition during pregnancy is known to affect many mechanisms including the neuroendocrine and neuroimmune systems in neonatal animals but effects on the APP are unknown. To investigate this phenomenon the serum concentration of Hp and SAA was initially determined in non-stimulated lambs from 3 groups (n = 10/group). The dams of the lambs of the respective groups were fed 100% of requirements throughout gestation (High/High; HH); 100% of requirements for the first 65 d of gestation followed by 70% of requirements until 125 d from when they were fed 100% of requirements (High/Low; HL); 65% of liveweight maintenance requirements for the first 65 d gestation followed by 100% of requirements for the remainder of pregnancy (Low/High; LH). The dynamic APP response in the lambs was estimated by measuring the concentration of Hp and SAA following routine vaccination with a multivalent clostridial vaccine with a Pasteurella component, Heptavac Ptrade mark following primary and secondary vaccination. The Hp and SAA con...Continue Reading

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Citations

Oct 16, 2009·Journal of the Royal Society, Interface·A R T JonkersR M Christley
Mar 8, 2011·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Lijing SunZhiguo Su
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Nov 8, 2016·Animal : an International Journal of Animal Bioscience·A DestrezV Deiss
Oct 2, 2021·Signal Transduction and Targeted Therapy·Cuicui MaZhenling Wang

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