Maternal viral load and hepatitis B virus mother-to-child transmission risk: A systematic review and meta-analysis

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Hong-Lin ChenGang Qin

Abstract

The aim of this study was to assess the relationship between maternal viral load and mother-to-child transmission (MTCT) risk in hepatitis B envelope antigen (HBeAg)-positive mothers. PubMed and Web of Science were systematically searched. We compared MTCT incidence between maternal hepatitis B virus (HBV)-DNA-positive and HBV-DNA-negative groups. We also examined the dose-response effect of this relationship. Twenty-one studies with 10 142 mother-child pairs were included in the studies. The mean MTCT incidence was 13.1% in the maternal HBV-DNA-positive group, compared with 4.2% in the negative group. The summary MTCT odds ratio of maternal HBV-DNA positive compared with negative was 9.895 (95% confidence interval [CI], 5.333 to 18.359; Z = 7.27, P < 0.00001) by random-effects model. In maternal HBV-DNA <6 log10 copies/mL, 6-8 log10 copies/mL, and >8 log10 copies/mL level stratifications, the pooled MTCT incidences were 2.754% (95% CI, 1.198-4.310%; Z = 3.47, P = 0.001), 9.932% (95% CI, 6.349-13.516%; Z = 5.43, P < 0.00001), and 14.445% (95% CI, 8.317-20.572%; Z = 4.62, P < 0.00001), respectively. A significant linear dose-response association was found between maternal viral load and MTCT risk, with the points estimate of inc...Continue Reading

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Citations

Mar 20, 2019·Journal of Pediatric Gastroenterology and Nutrition·Jamil N KanjiCarla Osiowy
Sep 22, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Rongfang HeXin Xie
Sep 3, 2019·Frontiers in Genetics·Zhenhua ZhangMengji Lu

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