Maternal Vitamin D Deficiency Causes Sustained Impairment of Lung Structure and Function and Increases Susceptibility to Hyperoxia-induced Lung Injury in Infant Rats.

American Journal of Respiratory Cell and Molecular Biology
Erica MandellSteven H Abman

Abstract

Vitamin D deficiency (VDD) during pregnancy is associated with increased respiratory morbidities and risk for chronic lung disease after preterm birth. However, the direct effects of maternal VDD on perinatal lung structure and function and whether maternal VDD increases the susceptibility of lung injury due to hyperoxia are uncertain. In the present study, we sought to determine whether maternal VDD is sufficient to impair lung structure and function and whether VDD increases the impact of hyperoxia on the developing rat lung. Four-week-old rats were fed VDD chow and housed in a room shielded from ultraviolet A/B light to achieve 25-hydroxyvitamin D concentrations <10 ng/ml at mating and throughout lactation. Lung structure was assessed at 2 weeks for radial alveolar count, mean linear intercept, pulmonary vessel density, and lung function (lung compliance and resistance). The effects of hyperoxia for 2 weeks after birth were assessed after exposure to fraction of inspired oxygen of 0.95. At 2 weeks, VDD offspring had decreased alveolar and vascular growth and abnormal airway reactivity and lung function. Impaired lung structure and function in VDD offspring were similar to those observed in control rats exposed to postnatal h...Continue Reading

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Citations

Jan 25, 2021·The Journal of Allergy and Clinical Immunology·Hanna M KnihtiläAugusto A Litonjua
Mar 19, 2021·American Journal of Respiratory and Critical Care Medicine·Robinder G KhemaniRémi Coudroy
Jun 15, 2021·American Journal of Respiratory and Critical Care Medicine·Erick FornoPaul D Robinson
Jun 18, 2021·American Journal of Respiratory Cell and Molecular Biology·Erica W Mandell

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Methods Mentioned

BETA
ELISA
PCR
protein assay

Software Mentioned

GraphPad
Prism

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