Maternal vitamin D supplementation during pregnancy prevents vitamin D deficiency in the newborn: an open-label randomized controlled trial

Clinical Endocrinology
Christine P RoddaB Vollenhoven

Abstract

To determine whether maternal vitamin D supplementation, in the vitamin D deficient mother, prevents neonatal vitamin D deficiency. Open-label randomized controlled trial. Metropolitan Melbourne, Australia, tertiary hospital routine antenatal outpatient clinic. Seventy-eight women with singleton pregnancies with vitamin D deficiency/insufficiency (serum 25-OH Vit D < 75 nmol/l) at their first antenatal appointment at 12-16-week gestation were recruited. Participants were randomized to vitamin D supplementation (2000-4000 IU cholecalciferol) orally daily until delivery or no supplementation. The primary outcome was neonatal serum 25-OH vit D concentration at delivery. The secondary outcome was maternal serum 25-OH vit D concentration at delivery. Baseline mean maternal serum 25-OH vit D concentrations were similar (P = 0·9) between treatment (32 nmol/l, 95% confidence interval 26-39 nmol/l) and control groups (33 nmol/l, 95% CI 26-39 nmol/l). Umbilical cord serum 25-OH vit D concentrations at delivery were higher (P < 0·0001) in neonates of treatment group mothers (81 nmol/l, 95% CI; 70-91 nmol/l) compared with neonates of control group mothers (42 nmol/l, 95% CI; 34-50 nmol/l) with a strongly positive correlation between matern...Continue Reading

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Citations

Mar 24, 2018·The Journal of Obstetrics and Gynaecology Research·Naoto YonetaniMinoru Irahara
Jul 31, 2019·International Journal of Endocrinology·Kaneshapillai AnushaGuwani Liyanage
Oct 4, 2019·The Cochrane Database of Systematic Reviews·Cristina PalaciosJuan Pablo Peña-Rosas
Feb 13, 2020·Genetics·Michela TragliaLauren A Weiss
Aug 28, 2020·The Cochrane Database of Systematic Reviews·Marian G ShowellRoger J Hart
Jan 1, 2015·Healthcare·Krista D SowellJanet Y Uriu-Adams
Jul 28, 2019·The Cochrane Database of Systematic Reviews·Cristina PalaciosJuan Pablo Peña-Rosas
May 31, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Samuel J Martínez-DomínguezFaustino R Pérez-López
Dec 10, 2016·Wiener klinische Wochenschrift·Andraž DovnikIztok Takač
May 13, 2021·Revista paulista de pediatria : orgão oficial da Sociedade de Pediatria de São Paulo·Letícia Veríssimo DutraTulio Konstantyner
Oct 9, 2021·Frontiers in Genetics·Aparna SampathkumarNeerja Karnani

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