Maternal Weaning Modulates Emotional Behavior and Regulates the Gut-Brain Axis.

Scientific Reports
Pamela FarshimAlexis Bailey

Abstract

Evidence shows that nutritional and environmental stress stimuli during postnatal period influence brain development and interactions between gut and brain. In this study we show that in rats, prevention of weaning from maternal milk results in depressive-like behavior, which is accompanied by changes in the gut bacteria and host metabolism. Depressive-like behavior was studied using the forced-swim test on postnatal day (PND) 25 in rats either weaned on PND 21, or left with their mother until PND 25 (non-weaned). Non-weaned rats showed an increased immobility time consistent with a depressive phenotype. Fluorescence in situ hybridization showed non-weaned rats to harbor significantly lowered Clostridium histolyticum bacterial groups but exhibit marked stress-induced increases. Metabonomic analysis of urine from these animals revealed significant differences in the metabolic profiles, with biochemical phenotypes indicative of depression in the non-weaned animals. In addition, non-weaned rats showed resistance to stress-induced modulation of oxytocin receptors in amygdala nuclei, which is indicative of passive stress-coping mechanism. We conclude that delaying weaning results in alterations to the gut microbiota and global metab...Continue Reading

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Citations

Feb 6, 2018·Reviews in the Neurosciences·Gal WinterChristopher F Sharpley
Nov 4, 2016·Neurochemical Research·Raeesah Maqsood, Trevor W Stone
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Dec 11, 2019·Neuroscience and Biobehavioral Reviews·Bogdana Golofast, Karel Vales

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Methods Mentioned

BETA
environmental stress
Fluorescence
bacterial translocation
NMR

Software Mentioned

MCID analyzer
SAS
SIMCA
Noldus EthoVision
GraphPad Prism
MATLAB

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