Maternally-derived Antibodies to Schizont Egress Antigen-1 and Protection of Infants From Severe Malaria

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Jonathan D KurtisMichal Fried

Abstract

In holoendemic areas, children suffer the most from Plasmodium falciparum malaria, yet newborns and young infants express a relative resistance to both infection and severe malarial disease (SM). This relative resistance has been ascribed to maternally-derived anti-parasite immunoglobulin G; however, the targets of these protective antibodies remain elusive. We enrolled 647 newborns at birth from a malaria-holoendemic region of Tanzania. We collected cord blood, measured antibodies to Plasmodium falciparum Schizont Egress Antigen-1 (PfSEA-1), and related these antibodies to the risk of severe malaria in the first year of life. In addition, we vaccinated female mice with PbSEA-1, mated them, and challenged their pups with P. berghei ANKA parasites to assess the impact of maternal PbSEA-1 vaccination on newborns' resistance to malaria. Children with high cord-blood anti-PfSEA-1 antibody levels had 51.4% fewer cases of SM compared to individuals with lower anti-PfSEA-1 levels over 12 months of follow-up (P = .03). In 3 trials, pups born to PbSEA-1-vaccinated dams had significantly lower parasitemia and longer survival following a P. berghei challenge compared to pups born to control dams. We demonstrate that maternally-derived, co...Continue Reading

References

Jun 12, 1976·Lancet·G PasvolH M Gilles
Jun 1, 1972·Archives of Disease in Childhood·L Iyengar, R J Selvaraj
Aug 1, 1969·Archives of Disease in Childhood·A I Williams, H McFarlane
Nov 5, 1999·Clinical and Diagnostic Laboratory Immunology·C NicoaraL Matter
Mar 10, 2001·Parasite Immunology·E M RileyK A Koram
Sep 1, 1952·Annals of Tropical Medicine and Parasitology·L J BRUCE-CHWATT
Dec 27, 1952·British Medical Journal·B G MAEGRAITHE S JONES
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Danielle I StanisicMichael F Good
Nov 2, 2005·PLoS Medicine·Theonest K MutabingwaPatrick E Duffy
May 27, 2008·The Journal of Infectious Diseases·Edward R KabyemelaPatrick E Duffy
Jan 12, 2012·Clinical & Developmental Immunology·Patricia PalmeiraMagda Carneiro-Sampaio
Sep 25, 2014·PloS One·Helga K EinarsdottirGestur Vidarsson
Jan 9, 2016·Parasitology·Katherine R Dobbs, Arlene E Dent
Nov 29, 2016·International Journal for Parasitology·Linda M MurungiFaith H A Osier

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