PMID: 6969774Dec 1, 1980Paper

Maternally transmitted target antigen for unrestricted killing by NZB T lymphocytes

The Journal of Experimental Medicine
K Fischer LindahlR Riblet

Abstract

A new target antigen for unrestricted killing was defined by NZB T lymphocytes which were immunized and restimulated with H-2-identical BALB/c spleen cells. These effector cells killed nearly all target cells tested, irrespective of their H-2 type, but did not kill NZB target cells. The response was shown to have three major components: unrestricted killing specific for Qed-1b, H-2d-restricted killing specific for minor histocompatibility antigens, and unrestricted killing specific for a new antigen, Mta. Mta is present on normal and mitogen-stimulated T and B lymphocytes and on several tumor lines. It was found on cells from 26 mouse strains tested, including two substrains of NZB, representing 9 different H-2 types and 14 different non-H-2 backgrounds. Analysis of the NX8 recombinant inbred lines (derived from Mta-NZB/Icr and Mta+C58/J parents) suggested that Mta is maternally transmitted. This was confirmed by typing of reciprocal F1 hybrids and backcrosses between positive and negative strains: Mta+ females bear Mta+ offspring and Mta- females Mta- offspring, irrespective of the phenotype of the males.

References

May 1, 1978·The Journal of Experimental Medicine·E S RavechéJ H Tjio
Jun 1, 1976·Scandinavian Journal of Immunology·H Wigzell
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Jan 1, 1980·International Archives of Allergy and Applied Immunology·M H Schreier, R Tees
Apr 1, 1980·European Journal of Immunology·K F Lindahl, B Hausmann

❮ Previous
Next ❯

Citations

Jan 1, 1987·Immunogenetics·A C HanR R Rich
Jan 1, 1986·Springer Seminars in Immunopathology·H H Shen, R J Winchester
Jun 1, 1996·Research in Immunology·C R WangJ Deisenhofer
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·K F Lindahl, K Bürki
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M M HustonR R Rich
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·H KosekiM Taniguchi
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C R Wang, K F Lindahl
Dec 1, 1982·The Journal of Experimental Medicine·R SmithR R Rich
Apr 1, 1991·The Journal of Experimental Medicine·J D DaviesD B Wilson
May 11, 1983·Nucleic Acids Research·S D FerrisA C Wilson
Jan 1, 1997·Annual Review of Immunology·K F LindahlM Yoshino
Feb 1, 1985·Journal of Immunogenetics·T OikawaT Yoshiki
Feb 1, 1982·European Journal of Immunology·K F LindahlL Flaherty
Jun 1, 1989·Journal of Immunogenetics·S WeissA Alanen
Dec 1, 1981·Scandinavian Journal of Immunology·K F Lindahl, J Langhorne
Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexander PlossEric G Pamer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.