Maternofetal transfer of antibodies and the influence of maternal atopic status on the neonate

American Journal of Rhinology & Allergy
Zizhong YuWeijia Kong

Abstract

Epidemiologic evidence has shown that sensitization of allergic diseases develops early in life, even before birth. The gestational environment, including maternal atopic status and transplacentally transferred antibodies to allergens, may be of importance in the sensitization process. To investigate maternofetal transfer of antibodies and the influence of maternal atopic status on the neonatal immune response. Fifty-seven healthy pregnant women who underwent elective cesarean section (ECS) were recruited. Total and specific IgE (Phadiatop) levels in cord blood (CB) and maternal blood (MB) were determined using the ImmunoCAP assay. MB- and CB-specific IgG1 and IgA1 antibodies against ovalbumin and house dust mite were analyzed by enzyme linked immunosorbent assay. The cytokines, interleukin (IL)-13, interferon (IFN)-γ, and IL-10 in the supernatant of cultured CB mononuclear cells were quantified by enzyme linked immunosorbent assay. Two subgroups were defined based on the maternal levels of specific IgE (atopic group, Phadiatop IgE more than or equal to 0.35 kilo international units of allergen-specific antibody (KUA)/L; nonatopic group, Phadiatop IgE less than 0.35 KUA/L). Although total IgE was detectable in all MB samples, i...Continue Reading

References

Jul 1, 1992·The Journal of Pediatrics·B R LúdvíkssonH Valdimarsson
Jan 1, 1989·American Journal of Obstetrics and Gynecology·W B PittardR U Sorensen
Aug 1, 1996·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·D R OwnbyE L Peterson
Jul 24, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G EdenharterU Wahn
Dec 22, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M C Jenmalm, B Björkstén
Nov 15, 2001·The Journal of Allergy and Clinical Immunology·J BousquetUNKNOWN World Health Organization
Apr 15, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R CasasB Björkstén
Apr 9, 2005·Early Human Development·Ariadne Malamitsi-PuchnerGeorge Creatsas
Sep 28, 2006·Clinical and Molecular Allergy : CMA·Ngoc P LyJuan C Celedón
Nov 1, 2006·Allergy·R J Boyle, M L K Tang
Mar 11, 2008·The Journal of Allergy and Clinical Immunology·Klaus BønnelykkeHans Bisgaard
Mar 26, 2008·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Toos C E M van Beijsterveldt, Dorret I Boomsma
Jan 30, 2009·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Martina SandbergMaria C Jenmalm
Mar 24, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·W-J KongY Zhou
May 15, 2009·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Hiromi TadakiAkihiro Morikawa
Nov 10, 2009·The Journal of Allergy and Clinical Immunology·Diane R GoldJames E Gern
May 7, 2010·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Tim H Scott-TaylorStephan Strobel
Sep 8, 2010·The Journal of Allergy and Clinical Immunology·Klaus BønnelykkeHans Bisgaard
Oct 14, 2010·Folia Microbiologica·J HrdýL Prokešová
Jul 21, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A K KukkonenM Kuitunen
Sep 3, 2011·Scandinavian Journal of Immunology·P MacchiaverniA Condino-Neto
Sep 29, 2011·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·William B HicksEdward M Zoratti
Apr 3, 2012·The Journal of Allergy and Clinical Immunology·Norio KamemuraHiroshi Kido
Sep 4, 2013·Allergy and Asthma Proceedings·Evelia HernándezIsabelle Romieu

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Citations

Apr 3, 2019·Journal of Cellular Biochemistry·Mohammad FereidouniMajid Arefi
Jul 3, 2021·International Journal of Environmental Research and Public Health·Chang-Ku TsaiHong-Ren Yu

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Methods Mentioned

BETA
cesarean section
enzyme linked immunosorbent assay

Software Mentioned

SPSS
Statistical Package for Social Sciences

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