PMID: 641805May 1, 1978Paper

Mathematical basis of point-area deconvolution method for determining in vivo input functions

Journal of Pharmaceutical Sciences
D P Vaughan, M Dennis

Abstract

The point-area method for deconvolution derives a "staircase" input function which, when convolved onto the characteristic function, gives an output function coincidental with the given output data points. The area--area method for deconvolution is shown to be erroneous.

Citations

Jan 1, 1984·European Journal of Clinical Pharmacology·G T TuckerD W Holt
Apr 1, 1994·European Journal of Drug Metabolism and Pharmacokinetics·J RichardJ Godbillon
Jan 1, 1981·Pharmacology & Therapeutics·D Cutler
Oct 31, 1998·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·C DuquesnoyE Fuseau
Nov 7, 2003·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Frieder Langenbucher
Jun 27, 2000·Environmental Toxicology and Pharmacology·P SartorelliF Williams
Jun 1, 1991·British Journal of Clinical Pharmacology·J DreweK Gyr
Feb 1, 1992·The Journal of Pharmacy and Pharmacology·S HedayatiM Rowland
Jun 1, 1995·The Journal of Pharmacy and Pharmacology·A B NoachD D Breimer
May 19, 1998·Anesthesia and Analgesia·J ZhangJ B Streisand
Aug 29, 2001·Clinical Pharmacokinetics·M L ChenR L Williams
Jan 1, 1986·European Journal of Clinical Pharmacology·P Vermeij, P van Brummelen
Jan 1, 1987·European Journal of Clinical Pharmacology·P J De SchepperJ M Van Rossum
Jul 3, 2015·Drug Development and Industrial Pharmacy·Ignacio González-GarcíaMarival Bermejo
Feb 17, 2009·Biometrical Journal. Biometrische Zeitschrift·Stephan Koehne-Voss, Iris Pigeot
Oct 1, 1983·American Heart Journal·D W HoltG C Storey
Feb 1, 1989·British Journal of Clinical Pharmacology·P A SoonsD D Breimer
Jan 1, 1985·British Journal of Clinical Pharmacology·F Langenbucher, J Mysicka
Oct 1, 1993·Journal of Pharmacokinetics and Biopharmaceutics·D Verotta
Aug 1, 1989·Journal of Pharmacokinetics and Biopharmaceutics·J B van BreeD D Breimer
Aug 1, 1989·Journal of Pharmacokinetics and Biopharmaceutics·D VerottaD R Stanski
Jun 1, 1983·Journal of Pharmacokinetics and Biopharmaceutics·N WatariN Kaneniwa
Dec 1, 1995·Journal of Pharmacokinetics and Biopharmaceutics·K E Fattinger, D Verotta
Dec 1, 1991·Journal of Pharmacokinetics and Biopharmaceutics·J E Peris-RiberaJ M Pla-Delfina
Jun 1, 1996·Journal of Pharmacokinetics and Biopharmaceutics·F N MaddenR A Bates
Aug 1, 1988·Journal of Pharmacokinetics and Biopharmaceutics·P Veng-Pedersen
Feb 1, 1980·Journal of Pharmacokinetics and Biopharmaceutics·D P Vaughan, M Dennis
Dec 1, 1987·Journal of Pharmacokinetics and Biopharmaceutics·M K Charter, S F Gull
Dec 1, 1987·Journal of Pharmacokinetics and Biopharmaceutics·V K Piotrovskii
Feb 1, 1988·Journal of Pharmacokinetics and Biopharmaceutics·S VajdaP Valko
Aug 1, 1979·Journal of Pharmacokinetics and Biopharmaceutics·W A Colburn
Oct 1, 1984·Journal of Pharmacokinetics and Biopharmaceutics·M NicklassonJ Sjövall
Apr 1, 1989·Journal of Pharmacokinetics and Biopharmaceutics·D Verotta
Jun 1, 1989·Journal of Pharmacokinetics and Biopharmaceutics·J M van RossumH W Teeuwen
Dec 1, 1989·Journal of Pharmacokinetics and Biopharmaceutics·K C Yeh, R D Small
Apr 1, 1986·Journal of Pharmacokinetics and Biopharmaceutics·K IgaT Shimamoto
Apr 1, 1979·Journal of Pharmacokinetics and Biopharmaceutics·D P Vaughan, I Hope
Nov 8, 2005·Drug Metabolism and Pharmacokinetics·Shoichi HaradaMitsuru Hashida
May 16, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Hong-Xiang YanJian-Ping Liu
Jan 1, 1996·European Journal of Clinical Pharmacology·K DahlstromA Kallen

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