Mathematical classification of regulatory logics for compound environmental changes

Journal of Theoretical Biology
Reiko J Tanaka, H Kimura

Abstract

This paper is concerned with biological regulatory mechanisms in response to the simultaneous occurrence of a huge number of environmental changes. The restricted resources of cells strictly limit the number of their regulatory methods; hence, cells must adopt, as compensation, special mechanisms to deal with the simultaneous occurrence of environmental changes. We hypothesize that cells use various control logics to integrate information about independent environmental changes related to a cell task and represent the resulting effects of the different ways of integration by logical functions. Using the notion of equivalence classes in set theory, we describe the mathematical classification of the effects into biologically unequivalent ones realized by different control logics. Our purely mathematical and systematic classification of logical functions reveals three elementary control logics with different biological relevance. To better understand their biological significance, we consider examples of biological systems that use these elementary control logics.

References

Dec 1, 1973·Journal of Theoretical Biology·R Thomas
Apr 1, 1973·Journal of Theoretical Biology·L Glass, S A Kauffman
Mar 1, 1996·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·T InadaH Aiba
Apr 21, 1999·Current Opinion in Cell Biology·M A Schwartz, V Baron
Jan 27, 2000·Cell·T Hunter
Nov 26, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Hamid Bolouri, Eric H Davidson
Apr 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Nicolas E BuchlerTerence Hwa
Jun 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Y SettyU Alon
Jan 7, 2004·Biotechnology and Bioengineering·William S HlavacekByron Goldstein
Feb 20, 2004·Journal of Bacteriology·Alison K HottesCraig Stephens
Mar 24, 2004·Nature Reviews. Microbiology·Douglas F Browning, Stephen J Busby
Sep 17, 2004·Cell·Jörg StellingJohn Doyle
Oct 19, 2004·Trends in Microbiology·Arnoud H M van VlietJohannes G Kusters
Mar 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sorin Istrail, Eric H Davidson
Mar 29, 2005·Nature Cell Biology·Satoru SasagawaShinya Kuroda
May 12, 2005·Journal of Theoretical Biology·Atsushi Mochizuki
May 27, 2005·Molecular Microbiology·Robert P Shivers, Abraham L Sonenshein
Apr 11, 2006·PLoS Biology·Avraham E MayoUri Alon
May 16, 2006·Nature Cell Biology·Madhusudan NatarajanRama Ranganathan
May 23, 2006·Biophysical Journal·Reiko J TanakaHidenori Kimura

❮ Previous
Next ❯

Citations

Mar 29, 2012·Journal of Biomedicine & Biotechnology·Juanyi YuTzyh-Jong Tarn
Aug 5, 2009·IEEE Transactions on Systems, Man, and Cybernetics. Part B, Cybernetics : a Publication of the IEEE Systems, Man, and Cybernetics Society·Shingo Shimoda, Hidenori Kimura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved