Mathematical, clinical, and laboratory study of hemodynamic changes in the placental circulation

Archives of Gynecology
L HeilmannH Ludwig

Abstract

Various rheological properties of blood were investigated in pregnant and non-pregnant women of similar age. The results from 27 women with abnormal pregnancies were compared to those obtained from 17 non-pregnant women. In abnormal pregnancies we found a reduction of the erythrocyte filtration and a pathological use in red cell aggregation and in the shear resistance of the aggregates. Fractional light transmission (T7/T0) was higher than 1.0, suggesting that pressure gradients in the capillary circulation are not sufficient to disperse red cell aggregates. Thus, rheological factors may be partly responsible for the clinical consequences of pre-eclampsia. Pathological red blood cell aggregation and stagnation are consequences of the changed flow properties in the microcirculation. Even a small decrease of the local pressure gradients in the microcirculation of patients with pre-eclampsia would impair the dispersal of red blood cells and lead to their increased aggregation. Complete occlusion of the placental circulation by these aggregates would impair oxygen transfer at a speed that has been calculated from a diffusion equation based on the concept of the placenta as a hollow cylinder.

References

Jan 1, 1977·Vox Sanguinis·K HummelW Schmidts
Jan 1, 1975·European Journal of Obstetrics, Gynecology, and Reproductive Biology·W MollJ Herberger
Aug 1, 1975·British Journal of Haematology·G W Richter
Sep 20, 1973·The American Journal of Cardiology·L Speroff
Sep 1, 1974·The British Journal of Ophthalmology·J WilliamsonW C Dick
Jan 1, 1974·European Journal of Obstetrics, Gynecology, and Reproductive Biology·N F Arts, A H Lohman
Apr 1, 1973·Australian and New Zealand Journal of Medicine·B E Hopkins, R R Taylor
Jan 1, 1972·Pflügers Archiv : European journal of physiology·H J KloseH Schmid-Schönbein
Jan 1, 1972·Acta Endocrinologica. Supplementum·R E Myers
Sep 1, 1971·The Journal of Experimental Zoology·D R Robertson
Apr 27, 1971·Archiv für Gynäkologie·H LudwigH Klingele
Jan 1, 1958·Archiv für Gynäkologie·G HORMANN
Nov 1, 1961·Canadian Anaesthetists' Society Journal·S G HERSHEY, B W ZWEIFACH
Apr 1, 1964·The Journal of Obstetrics and Gynaecology of the British Commonwealth·I BROSENS
Nov 7, 1947·Science·M H KniselyL Warner

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Citations

Jul 8, 2005·Archives of Gynecology and Obstetrics·Layla Francis Badria, Zouhair Odeh Amarin
Oct 24, 2015·Journal of Applied Physiology·A S SerovMarcel Filoche

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