Mathematical Methods for Measuring the Visually Enhanced Vestibulo-Ocular Reflex and Preliminary Results from Healthy Subjects and Patient Groups

Frontiers in Neurology
Jorge Rey-MartinezNicolas Perez-Fernandez

Abstract

Visually enhanced vestibulo-ocular reflex (VVOR) is a well-known bedside clinical test to evaluate visuo-vestibular interaction, with clinical applications in patients with neurological and vestibular dysfunctions. Owing to recently developed diagnostic technologies, the possibility to perform an easy and objective measurement of the VVOR has increased, but there is a lack of computational methods designed to obtain an objective VVOR measurement. To develop a method for the assessment of the VVOR to obtain a gain value that compares head and eye velocities and to test this method in patients and healthy subjects. Two computational methods were developed to measure the VVOR test responses: the first method was based on the area under curve of head and eye velocity plots and the second method was based on the slope of the linear regression obtained for head and eye velocity data. VVOR gain and vestibulo-ocular reflex (VOR) gain were analyzed with the data obtained from 35 subjects divided into four groups: healthy (N = 10), unilateral vestibular with vestibular neurectomy (N = 8), bilateral vestibulopathy (N = 12), and cerebellar ataxia, neuropathy, and vestibular areflexia syndrome (CANVAS) (N = 5). Intra-class correlation index...Continue Reading

References

Jul 1, 1988·Archives of Neurology·G M Halmagyi, I S Curthoys
May 1, 1986·Journal of Clinical Periodontology·N W Chilton, J L Fleiss
Jan 1, 1986·Biological cybernetics·D A RobinsonS E Gordon
Jan 1, 1985·Vision Research·C H MeyerD A Robinson
Jan 1, 1995·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J L Demer
Sep 11, 2002·Archives of Otolaryngology--head & Neck Surgery·Charles C Della SantinaLloyd B Minor
Nov 11, 2003·Brain : a Journal of Neurology·Americo A MigliaccioPhillip D Cremer
Dec 1, 2004·Neuroreport·Christopher J BockischThomas Haslwanter
Sep 7, 2006·The Laryngoscope·Moisés A ArriagaRebecca Y Arriaga
Oct 26, 2007·International Journal of Pediatric Otorhinolaryngology·Angelo SalamiRenzo Mora
Aug 4, 2009·Annals of the New York Academy of Sciences·Konrad P WeberIan S Curthoys
Sep 18, 2012·Revue neurologique·A Kheradmand, D S Zee
May 1, 2013·PloS One·Hamish Gavin MacdougallKonrad Peter Weber
Oct 30, 2013·Neurology·Jens Alexander PetersenKonrad Peter Weber
Dec 5, 2014·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Eusebi Matiño-SolerNicolas Perez-Fernandez
Dec 17, 2014·Audiology & Neuro-otology·Georgios MantokoudisDavid E Newman-Toker
Feb 27, 2016·Neurology. Clinical Practice·David J SzmulewiczElsdon Storey
Jun 23, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Salman F Alhabib, Issam Saliba
Jul 16, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Alexander A TarnutzerKonrad P Weber
Sep 16, 2016·Journal of Neurology·Miriam S WelgampolaG Michael Halmagyi
Sep 18, 2016·Handbook of Clinical Neurology·H Kingma, R van de Berg
Dec 13, 2016·Brain Structure & Function·R E RobertsA M Bronstein

❮ Previous
Next ❯

Citations

Feb 15, 2020·Ear and Hearing·Gabriel Trinidad-RuizNicolas Perez-Fernandez
Oct 5, 2020·The Cerebellum·Mathieu DupréCaroline Froment Tilikete
Feb 12, 2019·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Jorge Rey-MartinezXabier Altuna
Nov 17, 2020·Clinical and Experimental Otorhinolaryngology·Seong Hoon BaeSung Huhn Kim
Aug 15, 2021·Journal of Neurology·Gábor M HalmágyiLeigh A McGarvie
Dec 12, 2019·Audiology & Neuro-otology·Nicolás Pérez-FernándezRaquel Manrique-Huarte

❮ Previous
Next ❯

Software Mentioned

MATLAB
CANVAS
Octave Octave
vHIT
mldivide
PSPP PSPP
Octave

Related Concepts

Related Feeds

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

Related Papers

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
José GazullaPilar Larrodé
Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
David J SzmulewiczG Michael Halmagyi
© 2022 Meta ULC. All rights reserved