Mathematical model for low density lipoprotein (LDL) endocytosis by hepatocytes.

Bulletin of Mathematical Biology
J A D WattisKim Jackson

Abstract

Individuals with elevated levels of plasma low density lipoprotein (LDL) cholesterol (LDL-C) are considered to be at risk of developing coronary heart disease. LDL particles are removed from the blood by a process known as receptor-mediated endocytosis, which occurs mainly in the liver. A series of classical experiments delineated the major steps in the endocytotic process; apolipoprotein B-100 present on LDL particles binds to a specific receptor (LDL receptor, LDL-R) in specialized areas of the cell surface called clathrin-coated pits. The pit comprising the LDL-LDL-R complex is internalized forming a cytoplasmic endosome. Fusion of the endosome with a lysosome leads to degradation of the LDL into its constituent parts (that is, cholesterol, fatty acids, and amino acids), which are released for reuse by the cell, or are excreted. In this paper, we formulate a mathematical model of LDL endocytosis, consisting of a system of ordinary differential equations. We validate our model against existing in vitro experimental data, and we use it to explore differences in system behavior when a single bolus of extracellular LDL is supplied to cells, compared to when a continuous supply of LDL particles is available. Whereas the former si...Continue Reading

References

Jun 21, 1979·Nature·J L GoldsteinM S Brown
Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M S Brown, J L Goldstein
Mar 1, 1985·Biophysical Chemistry·P W ChunE E Brumbaugh
Sep 1, 1981·Cell Biophysics·B Goldstein, C Wofsy
Mar 10, 1999·The American Journal of Physiology·C D MamotteR R Taylor
Jun 29, 2002·The Journal of Nutritional Biochemistry·B H. Simon ChoByung Hong Chung
May 6, 2003·Nature Genetics·Marianne AbifadelCatherine Boileau
Nov 10, 2005·Journal of Lipid Research·Kim G JacksonChristine M Williams
Mar 29, 2006·Journal of Lipid Research·Karpagam AravindhanBeat M Jucker
Nov 3, 2006·The Journal of Clinical Investigation·Thomas A LagaceJay D Horton
Mar 6, 2007·Bulletin of Mathematical Biology·E AugustM Barahona
Jun 5, 2007·PLoS Computational Biology·Harish ShankaranH Steven Wiley
Aug 16, 2008·Journal of Mathematical Biology·T PearsonH M Byrne
Dec 27, 2008·Journal of Theoretical Biology·M J TindallK G Jackson

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Citations

Aug 16, 2008·Journal of Mathematical Biology·T PearsonH M Byrne
Oct 11, 2012·BMC Systems Biology·Mark T Mc AuleyThomas B L Kirkwood
Dec 27, 2008·Journal of Theoretical Biology·M J TindallK G Jackson
Aug 16, 2014·Bulletin of Mathematical Biology·T PearsonD J Mazzatti
Jul 6, 2015·Biochimica Et Biophysica Acta·Yared PaalvastAlbert K Groen
Jan 22, 2014·Journal of Theoretical Biology·Bonhi S BhattacharyaMarcus J Tindall
Jul 15, 2009·Molecular Oncology·Marc R Birtwistle, Boris N Kholodenko
Sep 26, 2017·PLoS Computational Biology·Stefan M KallenbergerDirk-Peter Herten
Aug 10, 2021·World Journal of Gastroenterology : WJG·Hui-Chun LiShih-Yen Lo
Dec 22, 2021·WIREs Mechanisms of Disease·Mark Tomás Mc Auley
Oct 7, 2019··Mladen VeletićIlangko Balasingham

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Software Mentioned

eqalign
Matlab
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ode45

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