Mathematical model for the blood coagulation prothrombin time test

Thrombosis Research
Michael A KhaninA E Kogan

Abstract

A mathematical model for the prothrombin time test is proposed. The time course of clotting factor activation during coagulation was calculated, and the sensitivity of the test to a decrease in the concentrations of coagulation proteins or their activities was studied. The model predicts that only severe coagulation disorders connected with a more than five-fold decrease in the concentrations or activities of the blood coagulation factors can be revealed by the test.

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Citations

Jan 25, 2006·Pathophysiology of Haemostasis and Thrombosis·Fazoil I Ataullakhanov, Mikhail A Panteleev
Aug 27, 2013·Journal of Theoretical Biology·Evgeny A ShavlyuginMikhail A Khanin
Sep 3, 2010·Computers in Biology and Medicine·J C Vanegas-AcostaD A Garzón-Alvarado
Jun 12, 2009·Clinical Pharmacology and Therapeutics·T WajimaS B Duffull
Sep 24, 2016·BMC Medical Informatics and Decision Making·Yuanyang ZhangLinda Petzold
Sep 25, 2007·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Donghui Zhu
Jul 19, 2001·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·A Kramoroff, J M Nigretto
Jun 17, 2020·Biophysical Journal·Christian J C BiscombeDalton J E Harvie

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