PMID: 3214756Sep 1, 1988Paper

Mathematical model of cellular mechanisms contributing to presynaptic facilitation

Brain Research Bulletin
K J GingrichJ H Byrne

Abstract

Presynaptic facilitation of transmitter release from sensory neurons is an important mechanism contributing to nonassociative and associative learning in Aplysia. In a previous modeling study (28,29), we concluded that enhancement of the postsynaptic potential (PSP) during presynaptic facilitation is mediated by at least two processes; spike broadening, which has been observed experimentally, and a process that we modeled as mobilization of transmitter. In an effort to gain insight into the relative contribution of these two mechanisms of presynaptic facilitation, we have extended our earlier model to include more detailed descriptions of: a) the kinetics of the Ca2+ channel, b) the diffusion of Ca2+ through the cytoplasm, c) the process of transmitter release, and d) the PSP. The present quantitative model provides an accurate description of the input-output relationship for synapses of sensory neurons, and predicts changes in the shape of postsynaptic potentials as a function of mobilization and spike broadening. The results confirm and extend previous experimental studies (33) and indicated that cellular analogs of sensitization (facilitation of nondecremented responses) is mediated primarily by spike broadening; whereas, an...Continue Reading

References

Jan 1, 1978·Annual Review of Biophysics and Bioengineering·F J Brinley
Sep 1, 1977·The Journal of Physiology·P G KostyukY A Shakhovalov
Jan 1, 1975·Biophysical Journal·J W MooreR W Joyner
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R S Zucker, A L Fogelson
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·B HochnerE R Kandel
Oct 1, 1985·The Journal of Physiology·G J AugustineS J Smith
Jun 1, 1987·Journal of Neurophysiology·K J Gingrich, J H Byrne
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C H Bailey, M Chen
Apr 1, 1987·Physiological Reviews·J H Byrne
Aug 1, 1971·The International Journal of Neuroscience·T J CarewE R Kandel
Jul 1, 1980·The Journal of Physiology·D J Adams, P W Gage
Nov 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·M Klein, E R Kandel
Jan 1, 1981·The Journal of Physiology·P G KostyukV I Pidoplichko
Mar 1, 1984·The Journal of Physiology·L ByerlyJ R Stimers
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M B BoyleE R Kandel
Jan 1, 1982·The Journal of Physiology·L Byerly, S Hagiwara
Sep 30, 1957·The Journal of Physiology·A L HODGKIN, R D KEYNES
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·B HochnerE R Kandel

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Citations

Jan 1, 1996·Biological cybernetics·E BlanzieriD Maio
Jun 1, 1991·Current Opinion in Neurobiology·D A Baxter, J H Byrne
May 5, 1998·Brain Research Bulletin·D Lundh
Jan 1, 1991·Annals of the New York Academy of Sciences·J H ByrneK P Scholz
Dec 22, 1999·Journal of Neurophysiology·D A BaxterJ H Byrne
Aug 9, 2006·Behavioral and Brain Functions : BBF·Chi-Sang Poon, Daniel L Young

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