Abstract
Apoptosis is an essential process to get rid of injured or unwanted cells. In this study, we proposed a mathematical modeling for death receptor mediated apoptosis to investigate the role of c-FLIP in controlling the balance between apoptosis and survival. In order to get insight into how NF-kappa B mediated pro-survival pathway affects the outcome of our modeling, we implemented reduced models without taking such regulation into consideration. Our simulation revealed that c-FLIP could act as a pivotal death or life switch and this switch-like behavior is bistable, irreversible, and robust. We introduce a new term, probability apoptosis, to delineate the likelihood in occurrence of apoptosis events. This simulation system is plausible and may offer several valuable clinical indications for the abnormal apoptosis related disease, such as cancer.
References
Jan 9, 1999·The Journal of Biological Chemistry·C ScaffidiM E Peter
Jun 6, 2000·Current Biology : CB·T KataokaJ Tschopp
Jul 21, 2001·Molecular and Cellular Biology·O MicheauJ Tschopp
Feb 21, 2002·The Journal of Clinical Investigation·Ralph C Budd
Nov 15, 2002·Cancer Biology & Therapy·Marc L HyerJames S Norris
Mar 17, 2004·Molecular and Cellular Biology·Takao Kataoka, Jürg Tschopp
Apr 14, 2004·The Journal of Experimental Medicine·Stephan MathasBernd Dörken
Jun 23, 2004·The Journal of Biological Chemistry·Thomas EissingPeter Scheurich
Jun 24, 2004·The Biochemical Journal·Kelly M BoatrightGuy S Salvesen
Dec 14, 2004·Arthritis and Rheumatism·Shaochun BaiRichard M Pope
Feb 22, 2005·Journal of Theoretical Biology·Jörg W Stucki, Hans-Uwe Simon
Apr 19, 2005·Critical Reviews in Immunology·Takao Kataoka
Jul 22, 2005·Carcinogenesis·David GilotChristiane Guguen-Guillouzo
Nov 24, 2005·Blood·Mauricio P OyarzoGeorge Z Rassidakis
Dec 13, 2005·Biophysical Journal·E Z BagciI Bahar
Jan 31, 2006·Expert Opinion on Therapeutic Targets·Amanda DuttonPaul G Murray
Jun 2, 2006·BMC Microbiology·Brandon W HiggsJordan C Feidler
Jun 17, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Constantine S MitsiadesNicholas Mitsiades
Sep 19, 2006·PLoS Computational Biology·Stefan LegewieHanspeter Herzel
Oct 10, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marc L HyerJohn C Reed
Dec 2, 2006·Chembiochem : a European Journal of Chemical Biology·Zhichao ZhangFengyu Liu
May 29, 2007·FEBS Letters·Hyung-Seok ChoiKwang-Hyun Cho
Jun 19, 2007·Cancer Research·Timothy R WilsonDaniel B Longley
Feb 22, 2008·Current Cancer Drug Targets·Ahmad R SafaChing-Huang Wu
Citations
Apr 23, 2013·Journal of Clinical Monitoring and Computing·Elife Zerrin BagciMehmet C Camurdan
Mar 20, 2009·Nature Immunology·Nicholas S WilsonAvi Ashkenazi
Dec 24, 2015·International Journal of Molecular Sciences·Yuichi TsuchiyaHiroyasu Nakano
Mar 23, 2012·Immunological Reviews·Soumen BasakAlexander Hoffmann