Mathematical modeling identified c-FLIP as an apoptotic switch in death receptor induced apoptosis

Apoptosis : an International Journal on Programmed Cell Death
Lihui HanXiaoqing Jia

Abstract

Apoptosis is an essential process to get rid of injured or unwanted cells. In this study, we proposed a mathematical modeling for death receptor mediated apoptosis to investigate the role of c-FLIP in controlling the balance between apoptosis and survival. In order to get insight into how NF-kappa B mediated pro-survival pathway affects the outcome of our modeling, we implemented reduced models without taking such regulation into consideration. Our simulation revealed that c-FLIP could act as a pivotal death or life switch and this switch-like behavior is bistable, irreversible, and robust. We introduce a new term, probability apoptosis, to delineate the likelihood in occurrence of apoptosis events. This simulation system is plausible and may offer several valuable clinical indications for the abnormal apoptosis related disease, such as cancer.

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Citations

Apr 23, 2013·Journal of Clinical Monitoring and Computing·Elife Zerrin BagciMehmet C Camurdan
Mar 20, 2009·Nature Immunology·Nicholas S WilsonAvi Ashkenazi
Dec 24, 2015·International Journal of Molecular Sciences·Yuichi TsuchiyaHiroyasu Nakano
Mar 23, 2012·Immunological Reviews·Soumen BasakAlexander Hoffmann

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis