Mathematical modeling of humoral immune response suppression by passively administered antibodies in mice

Journal of Theoretical Biology
Dokyun NaDoheon Lee

Abstract

Although passively administered antibodies are known to suppress the humoral immune response, the mechanism is not fully understood. Here, we developed a mathematical model to better understand the suppression phenomena in mice. Using this model, we tested the generally accepted but difficult to prove "epitope masking hypothesis." To simulate the hypothesis and clearly observe masking of epitopes, we modeled epitope-antibody and epitope-B-cell receptor interactions at the epitope level. To validate this model, we simulated the effect of the antibody affinity and quantity as well as the timing of administration on the suppression, and we compared the results with experimental observations reported in the literature. We then developed a simulation to determine whether the epitope-masking hypothesis alone can explain known immune suppression phenomena, especially the conflicting results on F(ab')2 fragment-induced suppression, which has been shown to be no suppression, or similar to or up to 1000-fold weaker than the suppression by intact antibody. We found that suppression was caused by a synergistic effect of both epitope masking and rapid antigen clearance. Although the latter hypothesis has lost support because FcgammaRI/III m...Continue Reading

References

Apr 12, 1975·British Medical Journal·J C WoodrowT M Gimlette
Apr 7, 1977·Journal of Theoretical Biology·P Waltman, E Butz
Jan 1, 1976·The Tohoku Journal of Experimental Medicine·E OuchiS Watabe
Apr 1, 1992·Immunological Reviews·T LeandersonD Gray
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A StrasserA W Harris
Sep 1, 1987·European Journal of Immunology·I Z QuintanaG Möller
Jul 1, 1968·The Journal of Experimental Medicine·C Henry, N K Jerne
Apr 21, 1981·Journal of Theoretical Biology·K Beck
Jan 1, 1994·Annual Review of Immunology·I C MacLennan
Jul 1, 1996·The Journal of Experimental Medicine·P D HodgkinA B Lyons
Aug 1, 1997·Seminars in Immunology·S HanG Kelsoe
Jan 31, 1998·The Journal of Experimental Medicine·P C WilsonV Pascual
Jan 16, 1998·Immunology and Cell Biology·D A Fulcher, A Basten
Jun 25, 1998·Current Opinion in Immunology·D Tarlinton
Oct 15, 1998·The Journal of Pathology·K Hollowood, J R Goodlad
Nov 6, 1998·Journal of Theoretical Biology·G A FunkU Kalinke
Oct 6, 2000·Science·J V Ravetch, L L Lanier
Jan 4, 2001·Current Opinion in Hematology·L J McHeyzer-WilliamsM G McHeyzer-Williams
Apr 4, 2001·Scandinavian Journal of Immunology·M C KarlssonB Heyman
Apr 5, 2001·Trends in Immunology·B M Kumpel, C J Elson
Sep 11, 2002·Obstetrics and Gynecology·Kenneth J Moise
Oct 18, 2002·Immunology·Liliana Guzman-RojasHector Martinez-Valdez
Apr 13, 1963·British Medical Journal·C A CLARKEP M SHEPPARD
Jun 1, 1965·The Journal of Experimental Medicine·G MOLLER, H WIGZELL
Feb 14, 2004·Immunological Reviews·Jeffrey C Rathmell
Mar 17, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Daniel S WarrenRobert A Montgomery
Jun 18, 2004·Molecular Cell·Susan Harless Smith, Michael Reth
May 12, 2005·Current Opinion in Immunology·Cassy L CozineThomas J Waldschmidt

❮ Previous
Next ❯

Citations

Jul 2, 2016·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Angjelina KoniniSeyed M Moghadas
Jul 29, 2015·Biochemical Pharmacology·Jie Luo, Jon Lindstrom
Jul 9, 2014·Molecular Immunology·Anna SörmanBirgitta Heyman
Aug 15, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Honghui YuAlan H Lazarus
Jul 19, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lidice BernardoAlan H Lazarus
Oct 8, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jie Luo, Jon Lindstrom

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
M C KarlssonBirgitta Heyman
Scandinavian Journal of Immunology
M C KarlssonBirgitta Heyman
The Journal of Immunology : Official Journal of the American Association of Immunologists
M C KarlssonBirgitta Heyman
© 2021 Meta ULC. All rights reserved