PMID: 11916512Mar 28, 2002Paper

Mathematical modeling of myoglobin facilitated transport of oxygen in devices containing myoglobin-expressing cells

Mathematical Biosciences
H K TilakaratneV G J Rodgers

Abstract

Low pO(2) is perhaps the most significant factor in artificial pancreas failure. In these environments, not only is the beta cell production of insulin reduced, but the cell death rate is also significantly higher. Mathematical models are developed to test the feasibility of facilitated oxygen transport in enhancing O(2) flux to genetically engineered cells in a bioartificial device such as a pancreas. For this device, it is proposed that beta cells be genetically engineered to express myoglobin throughout the cell. In addition, the significance of including myoglobin throughout the alginate matrix present to provide immuno-protection for the transplanted cells is considered. The mathematical analysis predicts that myoglobin facilitated oxygen transport has the potential of increasing the oxygen concentration at the centre of a cluster of cells (islet) with an effective radius of 100 microm by 50%. These theoretical models for myoglobin facilitated oxygen transport with homogeneous Michaelis-Menten consumption also indicate that including myoglobin in the alginate gel would beneficially improve the flux of oxygen to the transplanted cells.

References

May 1, 1991·Journal of Biomechanical Engineering·C K Colton, E S Avgoustiniatos
Apr 1, 1973·Diabetologia·P M Dean
Aug 1, 1983·Canadian Journal of Biochemistry and Cell Biology = Revue Canadienne De Biochimie Et Biologie Cellulaire·P G Scott
May 1, 1993·Journal of Applied Physiology·H MengR N Pittman
Nov 1, 1983·Archives of Disease in Childhood

❮ Previous
Next ❯

Citations

Mar 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Barbara LudwigUriel Barkai
Nov 18, 2009·Biochemistry. Biokhimii︠a︡·G B PostnikovaE A Shekhovtsova
Apr 18, 2009·Theoretical Biology & Medical Modelling·Peter Buchwald
Apr 12, 2016·The American Journal of Emergency Medicine·Liqiong YaoYunlin Tian
Jan 18, 2003·Archives of Physiology and Biochemistry·L MarzoukiM Amri
Oct 10, 2012·Cell Transplantation·Uriel BarkaiAvi Rotem
Apr 2, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Wilson Radding, George N Phillips

❮ Previous
Next ❯

Related Concepts

Related Feeds