Mathematical modeling of regulatory mechanisms in yeast colony development

Journal of Theoretical Biology
Th WaltherTh Bley

Abstract

In the present study, yeast colony development serves as a model system to study growth of fungal populations with negligible nutrient and signal transport within the mycelium. Mathematical simulations address the question whether colony development is governed by diffusional limitation of nutrients. A hybrid one-dimensional cellular automaton model was developed that describes growth of discrete cells based upon microscopic interaction rules in a continuous field of nutrient and messenger. The model is scaled for the geometry of the experimental setup, cell size, growth- and substrate uptake rates. Therefore, calculated cell density profiles and nutrient distributions can be compared to experimental results and the model assumptions can be verified. In the physiologically relevant parameter range, simulations show an exponentially declining cell density along the median axis of the colonies in case of a diffusion limited growth scenario. These results are in good agreement with cell density profiles obtained in cultivations of the yeast Candida boidinii with glucose as the limiting carbon source but stand in contrast to the constant cell density profile estimated for Yarrowia lipolytica grown under the same conditions. While f...Continue Reading

References

Dec 1, 1994·Microbiology·N A Gow
Nov 25, 1998·Journal of Theoretical Biology·F A Davidson
Dec 3, 1999·Biotechnology and Bioengineering·E E BeulingS P Ottengraf
Jan 19, 2000·Molecular Biology of the Cell·M C LorenzJ Heitman
Jun 27, 2001·Applied and Environmental Microbiology·J M HornbyK W Nickerson
Jan 15, 2002·Biotechnology and Bioengineering·Gülnur BirolAli Cinar
Nov 14, 2002·Molecular Biology of the Cell·Zdena PalkováClaude Jacq

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Citations

Nov 13, 2013·Bioprocess and Biosystems Engineering·Felix LenkThomas Bley
Feb 9, 2011·Progress in Biophysics and Molecular Biology·Marco SciannaLuigi Preziosi
Nov 10, 2015·Journal of Theoretical Biology·Rafał WcisłoWitold Dzwinel
Mar 13, 2016·Mathematical Biosciences·R AllenaL Preziosi
May 4, 2007·Yeast·Chris C Stowers, Erik M Boczko
Feb 3, 2005·Yeast

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