Apr 21, 2009

Mathematical modeling of the fluid dynamics in the flow-through cell

International Journal of Pharmaceutics
Maziar Kakhi


The fluid dynamics in the flow-through cell (USP apparatus 4) has been predicted using the mathematical modeling approach of computational fluid dynamics (CFD). The degree to which flow structures in this apparatus can be qualified as 'ideal' both spatially and temporally has been assessed. The simulations predict the development of the velocity field in this apparatus for configurations with and without beads during the discharge stroke of the pump. When the cell is operated only with the red ruby bead ('open column' mode), highly non-uniform flow is predicted just downstream of the bead in the latter stages of the pump's pulse. In contrast, a strong degree of profile uniformity and symmetry is predicted throughout the entire pulse in the region of the tablet holder for both standard configurations involving beads. However, noticeable differences in the tablet shear stress distribution are predicted at times when the same instantaneous inlet flow rates are being pumped through the apparatus. This effect is caused by flow separation in the velocity boundary layer formed around the tablet under the influence of an adverse pressure gradient, an effect not predicted with constant (non-pulsating) flow. While the degree of tablet er...Continue Reading

  • References12
  • Citations13


  • References12
  • Citations13


Mentioned in this Paper

In Silico
Anatomical Layer
Physiologic Pulse
Lycium andersonii
Contraction (Finding)
Erosion Lesion
Superficial Ulcer

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Vibeke Hougaard SunesenAnette Müllertz
Journal of Controlled Release : Official Journal of the Controlled Release Society
C A FyfeB J Fahie
© 2020 Meta ULC. All rights reserved