DOI: 10.1101/475285Nov 20, 2018Paper

Mathematical Modeling Reveals the Factors Involved in the Phenomena of Cancer Stem Cells Stabilization

BioRxiv : the Preprint Server for Biology
Nadya MorozovaA. Harel-Bellan

Abstract

Cancer Stem Cells (CSC), a subset of cancer cells resembling normal stem cells with self-renewal and asymmetric division capabilities, are present at various but low proportions in many tumors and are thought to be responsible for tumor relapses following conventional cancer therapies. In vitro, most intriguingly, when isolated, CSCs return to their original proportion level as shown by various investigators. This phenomenon still remains to be explained. We suggest a mathematical model of cancer cell population dynamics, based on the main parameters of cell population dynamics, including the proliferation rates, the rates of cell death and the frequency of symmetric and asymmetric cell divisions both in CSCs and in non-CSCs. This model should help elucidating some important factors underlying the dynamics of the two populations.

Related Concepts

Cell Death
Clinical Investigators
Neoplasms
Stem Cells
Recurrent Disease
Tumor Cells, Malignant
Cancer Treatment
Asymmetric Cell Division
Stem Cell Self-Renewal
Population Group

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