Mathematical Modelling and Prediction of the Effect of Chemotherapy on Cancer Cells

Scientific Reports
Hamidreza NamaziAlbert Wong

Abstract

Cancer is a class of diseases characterized by out-of-control cells' growth which affect DNAs and make them damaged. Many treatment options for cancer exist, with the primary ones including surgery, chemotherapy, radiation therapy, hormonal therapy, targeted therapy and palliative care. Which treatments are used depends on the type, location, and grade of the cancer as well as the person's health and wishes. Chemotherapy is the use of medication (chemicals) to treat disease. More specifically, chemotherapy typically refers to the destruction of cancer cells. Considering the diffusion of drugs in cancer cells and fractality of DNA walks, in this research we worked on modelling and prediction of the effect of chemotherapy on cancer cells using Fractional Diffusion Equation (FDE). The employed methodology is useful not only for analysis of the effect of special drug and cancer considered in this research but can be expanded in case of different drugs and cancers.

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Citations

Jul 5, 2016·BioMed Research International·Hamidreza NamaziSina Nazeri
May 28, 2016·International Journal for Numerical Methods in Biomedical Engineering·Hamidreza Namazi, Vladimir V Kulish
Oct 5, 2016·BioMed Research International·Hamidreza NamaziVladimir V Kulish
Nov 1, 2016·Bioscience Trends·Hamidreza NamaziVladimir V Kulish
Dec 9, 2016·Scientific Reports·Hamidreza Namazi, Vladimir V Kulish
Sep 11, 2019·Biomechanics and Modeling in Mechanobiology·Jiao ChenFred J Vermolen
Oct 16, 2019·Computational and Mathematical Methods in Medicine·Sara B MkangoTwalib Ngoma
Dec 2, 2020·Computer Methods and Programs in Biomedicine·M SaleemM Noman
Apr 3, 2020·Computer Methods and Programs in Biomedicine·M Younus BabaAbdur Raheem
Nov 3, 2021·Nano Convergence·Jessica A Kemp, Young Jik Kwon

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Software Mentioned

MATLAB

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