Mathematical modelling of energy expenditure during tissue deposition

The British Journal of Nutrition
Kevin D Hall

Abstract

Predicting the magnitude and rate of weight gain for a given increase of energy intake requires a model of whole-body energy expenditure that includes the energy cost of tissue deposition. Here, I introduce a mathematical framework for modelling energy expenditure that elucidates conceptual problems with the classical Kielanowski method for estimating the efficiencies of body fat and protein deposition. An alternative approach uses the theoretical biochemical efficiencies for protein and fat synthesis in combination with models of energy expenditure that include body fat and protein turnover costs. I illustrate this alternative approach using a simple mathematical model applied to previously published data from growing rats and human infants and compare the simple model results with the classical Kielanowski model. While both models fit the data reasonably well (R2>0.87 in rats and R2>0.67 in infants), the Kielanowski method resulted in parameter estimates that varied widely across experiments, had poor precision, and occasionally produced efficiency estimates greater than 1. In contrast, the new method provided precise parameter values and revealed consistencies across different experiments. The proposed mathematical framework...Continue Reading

References

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Jan 17, 2008·Obesity·Nancy F ButteThorkild I A Sørensen
Dec 10, 2008·The American Journal of Clinical Nutrition·Kevin D Hall, Peter N Jordan

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Citations

Oct 26, 2013·Journal of Pharmacokinetics and Pharmacodynamics·Peter GennemarkJohan Gabrielsson
May 1, 2012·Annual Review of Nutrition·Kevin D Hall
Aug 18, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Mohamed EddouksNaoufel Ali Zeggwagh
Aug 7, 2012·Disease Models & Mechanisms·John R Speakman, Klaas R Westerterp
May 13, 2011·The American Journal of Clinical Nutrition·Kevin D Hall, Carson C Chow
Mar 26, 2014·Physiology & Behavior·Dale A Schoeller
Oct 25, 2014·Irish Journal of Medical Science·I G MurphyE J Heffernan
Aug 30, 2011·Lancet·Kevin D HallBoyd A Swinburn
Oct 27, 2010·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·D T LevyB Swinburn
Apr 30, 2015·Global Health Promotion·Robert M Ojiambo
May 9, 2012·American Journal of Human Biology : the Official Journal of the Human Biology Council·Michelle LamplRoberto Romero
Aug 1, 2014·The American Journal of Clinical Nutrition·Kevin D Hall
Aug 8, 2014·The American Journal of Clinical Nutrition·Ele FerranniniRudolph L Leibel

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