Mathematical modelling of expanded bed adsorption - a perspective on in silico process design

Journal of Chemical Technology and Biotechnology
Victor KoppejanMarcel Ottens

Abstract

Expanded bed adsorption (EBA) emerged in the early 1990s in an attempt to integrate the clarification, capture and initial product concentration/purification process. Several mathematical models have been put forward to describe its operation. However, none of the models developed specifically for EBA allows simultaneous prediction of bed hydrodynamics, mass transfer/adsorption and (unwanted) interactions and fouling. This currently limits the development and early optimization of EBA-based separation processes. In multiphase reactor engineering, the use of multiphase computational fluid dynamics has been shown to improve fundamental understanding of fluidized beds. To advance EBA technology, a combination of particle, equipment and process scale models should be used. By employing a cascade of multiscale simulations, the various challenges EBA currently faces can be addressed. This allows for optimal design and selection of equipment, materials and process conditions, and reduces risks and development times of downstream processes involving EBA. © 2018 The Authors. Journal of Chemical Technology & Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

References

Jul 9, 1999·Biotechnology and Bioengineering·H M Fernandez-LahoreJ Thommes
May 2, 2001·Journal of Chromatography. a·E PålssonP O Larsson
Feb 22, 2002·Biotechnology and Bioengineering·Jürgen J HubbuchOwen R T Thomas
Aug 3, 2002·Biotechnology Progress·Maria B DainiakBo Mattiasson
Aug 30, 2002·Journal of Chromatography. a·Irini TheodossiouTimothy J Hobley
Nov 15, 2002·Biotechnology and Bioengineering·Dong-Qiang LinJörg Thömmes
Jan 31, 2003·Biotechnology and Bioengineering·Frédérique FenneteauRobert Legros
Jun 5, 2004·Biotechnology Progress·Krzysztof Kaczmarski, Jean-Christophe Bellot
Jul 29, 2004·Biotechnology and Bioengineering·Todd J Menkhaus, Charles E Glatz
Mar 31, 2009·Journal of Chromatography. a·Caroline Costa MoraesSusana Juliano Kalil
Jul 8, 2010·Journal of Bioscience and Bioengineering·Rami Reddy Vennapusa, Marcelo Fernandez-Lahore
Sep 28, 2010·Journal of Chromatography. a·A ArpanaeiO R T Thomas
Feb 16, 2013·Journal of Chromatography. a·Caroline Costa MoraesSusana Juliano Kalil
Mar 13, 2014·Biotechnology Progress·Chris JohnsonChris Antoniou
Mar 19, 2014·Trends in Biotechnology·Alexander T Hanke, Marcel Ottens

❮ Previous
Next ❯

Methods Mentioned

BETA
packed bed chromatography

Software Mentioned

Ansys Fluent
PIC
MP

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Related Papers

Journal of the Science of Food and Agriculture
Khairudin NurulhudaKarel J Keesman
Journal of Chemical Technology and Biotechnology
Hary Demey-CedeñoAna Maria Sastre
Journal of Chemical Technology and Biotechnology
Anton A KissTom Van Gerven
Journal of Chemical Technology and Biotechnology
Daniel BurgstallerPeter Satzer
© 2022 Meta ULC. All rights reserved