Mathematical modelling of leprosy and its control

Advances in Parasitology
David J BlokJan Hendrik Richardus

Abstract

Leprosy or Hansen's disease is an infectious disease caused by the bacterium Mycobacterium leprae. The annual number of new leprosy cases registered worldwide has remained stable over the past years at over 200,000. Early case finding and multidrug therapy have not been able interrupt transmission completely. Elimination requires innovation in control and sustained commitment. Mathematical models can be used to predict the course of leprosy incidence and the effect of intervention strategies. Two compartmental models and one individual-based model have been described in the literature. Both compartmental models investigate the course of leprosy in populations and the long-term impact of control strategies. The individual-based model focusses on transmission within households and the impact of case finding among contacts of new leprosy patients. Major improvement of these models should result from a better understanding of individual differences in exposure to infection and developing leprosy after exposure. Most relevant are contact heterogeneity, heterogeneity in susceptibility and spatial heterogeneity. Furthermore, the existing models have only been applied to a limited number of countries. Parameterization of the models for...Continue Reading

Citations

Aug 18, 2016·PLoS Neglected Tropical Diseases·Rebecca Lee Smith
Jun 4, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Graham F MedleyJan Hendrik Richardus
Aug 5, 2020·PLoS Neglected Tropical Diseases·Anuj TiwariJan Hendrik Richardus
Oct 23, 2015·Parasites & Vectors·David J BlokJan Hendrik Richardus
Mar 5, 2016·PLoS Neglected Tropical Diseases·Haroldo José de MatosJan Hendrik Richardus
Mar 15, 2018·Frontiers in Immunology·Mariateresa CoppolaAnnemieke Geluk
Jan 25, 2020·Indian Journal of Dermatology, Venereology and Leprology·Aparna Palit, Hemanta Kumar Kar
Feb 26, 2021·PLoS Neglected Tropical Diseases·Anneke T TaalJan Hendrik Richardus
Apr 1, 2021·PLoS Neglected Tropical Diseases·David J BlokJan Hendrik Richardus
Nov 14, 2020·Infectious Diseases of Poverty·Peter SteinmannW Cairns S Smith

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