Mathematical modelling of tumour acidity

Journal of Theoretical Biology
Kieran SmallbonePhilip Maini

Abstract

Acid-mediated tumour invasion is receiving increasing experimental and clinical attention. Previous models proposed to describe this phenomenon failed to capture key properties of the system, such as the existence of the benign steady state, or predicted incorrectly the size of the inter-tissue gap. Here we show that taking proper account of quiescence ameliorates these drawbacks as well as revealing novel behaviour. The simplicity of the model allows us to fully identify the key parameters controlling different aspects of behaviour.

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Citations

Jul 26, 2012·Journal of Mathematical Biology·David DiegoVíctor M Pérez-García
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May 29, 2015·Journal of Enzyme Inhibition and Medicinal Chemistry·Luana LuginiStefano Fais

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