Mathematical models of immune-induced cancer dormancy and the emergence of immune evasion

Interface Focus
Kathleen P Wilkie, Philip Hahnfeldt

Abstract

Cancer dormancy, a state in which cancer cells persist in a host without significant growth, is a natural forestallment of progression to manifest disease and is thus of great clinical interest. Experimental work in mice suggests that in immune-induced dormancy, the longer a cancer remains dormant in a host, the more resistant the cancer cells become to cytotoxic T-cell-mediated killing. In this work, mathematical models are used to analyse the possible causative mechanisms of cancer escape from immune-induced dormancy. Using a data-driven approach, both decaying efficacy in immune predation and immune recruitment are analysed with results suggesting that decline in recruitment is a stronger determinant of escape than increased resistance to predation. Using a mechanistic approach, the existence of an immune-resistant cancer cell subpopulation is considered, and the effects on cancer dormancy and potential immunoediting mechanisms of cancer escape are analysed and discussed. The immunoediting mechanism assumes that the immune system selectively prunes the cancer of immune-sensitive cells, which is shown to cause an initially heterogeneous population to become a more homogeneous, and more resistant, population. The fact that thi...Continue Reading

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Related Concepts

Immune Response
Immune System
Immune Evasion
T-Lymphocyte
Neoplasms
Tumor Cells, Malignant
Entire Immune System
Prune preparation
Dormancy
Disintegration (Morphologic Abnormality)

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