Matricellular Proteins: Functional Insights From Non-mammalian Animal Models.

Current Topics in Developmental Biology
Josephine C Adams

Abstract

The extracellular matrix (ECM) has central roles in tissue integrity and remodeling throughout the life span of animals. While collagens are the most abundant structural components of ECM in most tissues, tissue-specific molecular complexity is contributed by ECM glycoproteins. The matricellular glycoproteins are categorized primarily according to functional criteria and represented predominantly by the thrombospondin, tenascin, SPARC/osteonectin, and CCN families. These proteins do not self-assemble into ECM fibrils; nevertheless, they shape ECM properties through interactions with structural ECM proteins, growth factors, and cells. Matricellular proteins also promote cell migration or morphological changes through adhesion-modulating or counter-adhesive actions on cell-ECM adhesions, intracellular signaling, and the actin cytoskeleton. Typically, matricellular proteins are most highly expressed during embryonic development. In adult tissues, expression is more limited unless activated by cues for dynamic tissue remodeling and cell motility, such as occur during inflammatory response and wound repair. Many insights in the complex roles of matricellular proteins have been obtained from studies of gene knockout mice. However, wi...Continue Reading

Citations

Dec 12, 2018·Stem Cells Translational Medicine·Franca M R WitjasTon J Rabelink
Apr 23, 2020·American Journal of Physiology. Cell Physiology·Olga Stenina-Adognravi, Josephine C Adams
Jul 21, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Santoshi MuppalaOlga Stenina-Adognravi
Aug 28, 2020·American Journal of Physiology. Cell Physiology·Kyoko Imanaka-YoshidaToshimichi Yoshida
Sep 11, 2020·Scientific Reports·Supawich MorkmuedKaren Niederreither
Nov 23, 2020·Journal of Cellular Physiology·Chao SunXinhui Liu
Jan 23, 2021·International Journal of Molecular Sciences·Anna Di VitoGiuseppe Donato
Mar 26, 2021·Frontiers in Immunology·Saori YonebayashiKyoko Imanaka-Yoshida
Apr 4, 2021·Cells·Andrew E PouwElliott H Sohn

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