Matrilsin expression is a useful marker of submucosal invasion and lymph node metastasis in early stage signet ring cell carcinoma of the stomach

Journal of Surgical Oncology
Ryuusuke AiharaHiroyuki Kuwano

Abstract

Matrilysin (MMP-7) is considered to play an important role in tumor progression and metastasis. The aim of this study was to examine the MMP-7 expression of early-stage undifferentiated gastric carcinoma, and to investigate differences between gastric signet ring cell (SIG) and other undifferentiated carcinomas (non-SIG). Immunohistochemical staining of MMP-7 was performed using specimens from 150 patients with early-stage gastric undifferentiated carcinomas (76 SIG, 74 non-SIG). SIG had a larger proportion of mucosal-confined carcinoma and a lower rate of lymphatic invasion than non-SIG (P < 0.05). The incidence of the positive expression of MMP-7 in submucosal SIG was significantly higher than that of mucosal SIG (P < 0.01). In contrast, MMP-7 expression was frequently found in mucosal non-SIG, suggesting an apparent difference in the invasiveness between mucosal SIG and non-SIG. The larger the size of the mucosal SIG, the more frequently MMP-7 positive expression was demonstrated (P < 0.05). There was a significant correlation between MMP-7 positive expression and lymph node metastasis of early SIG (P < 0.05). Early SIG revealed less invasiveness than non-SIG in terms of clinicopathologic features and MMP-7 expression. Preop...Continue Reading

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Citations

Sep 8, 2010·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Woo Chul ChungYun Kyung Lee
Mar 20, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Selja KoskensaloCaj Haglund
Jan 9, 2008·International Journal of Immunopathology and Pharmacology·E Patraki, M R Cardillo
Sep 19, 2020·Cancer Management and Research·Yang LiYantao Tian

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