Matrilysin-1 (MMP-7) and MMP-19 are expressed by Paget's cells in extramammary Paget's disease

Journal of Cutaneous Pathology
Tiina KuivanenU Saarialho-Kere

Abstract

Extramammary Paget's disease (EMPD) is a rare malignant neoplasm of apocrine gland bearing skin characterized by intraepidermal proliferation of adenocarcinoma cells. Tumor growth depends on the ability of tumor cells to migrate by proteolysis and on angiogenesis. The matrix metalloproteinase (MMP) enzymes have been implicated in both of these processes in other types of skin cancer. The expression of MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, and MMP-19 was analyzed by immuno- histochemistry and/or in situ hybridization in 27 EMPD and five mammary PD (MMPD) specimens. The distribution of laminin-5 (LN-5) and tenascin-C, two extracellular matrix proteins associated with tumor invasion, was studied by immunohistochemistry. MMP-7 (matrilysin-1) and MMP-19 were the most frequently expressed MMPs in Paget's cells. Overexpression of MMP-2, MMP-9, or MMP-13, which is seen in many cancers, was not evident in EMPD. LN-5 and tenascin-C positivity did not correlate with the level of invasion. MMP-7, MMP-13, and MMP-19 were detected abundantly in MMPD, while MMP-9 was absent. MMP expression did not generally associate with the level of invasion of EMPD. In three samples positive for MMP-7 and four samples positive for MMP-19, an underlyin...Continue Reading

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Citations

Jun 11, 2010·The American Journal of Dermatopathology·Akihiro MiyamotoChihaya Maesawa
Aug 1, 2007·World Journal of Surgery·Tor W ChiuAndrew Burd
Mar 13, 2008·Journal of Cutaneous Pathology·Klaus Sellheyer, Dieter Krahl
Oct 1, 2009·Journal of Cutaneous Pathology·Shi-Jun ShanHong-Duo Chen
Oct 1, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Yuuko TohmatsuTsutomu Fujii

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